Solid-Liquid Equilibrium Modeling and Analysis of Acetylcysteine in 12 Pure Solvents

被引：1
|
作者：
Shu, Junning [1 ]
Li, Peizhou [1 ]
Huang, Xin [2 ,3 ]
Cheng, Xiaowei [1 ]
Wang, Na [2 ,3 ]
Hao, Hongxun [1 ,2 ,3 ]
机构：
[1] Hainan Univ, Sch Chem Engn & Technol, Hainan Prov Key Lab Fine Chem, Haikou 570228, Hainan, Peoples R China
[2] Tianjin Univ, Natl Engn Res Ctr Ind Crystallizat Technol, Sch Chem Engn & Technol, Tianjin 30072, Peoples R China
[3] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2023年 / 68卷 / 12期
基金：
海南省自然科学基金;
关键词：
DISSOLUTION THERMODYNAMIC PROPERTIES; GLUTARIC ACID; SOLUBILITY; PARAMETERS; MIXTURES; WATER;
D O I：
10.1021/acs.jced.3c00458
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In this work, the solubility of acetylcysteine in 12 pure solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, dimethylformamide, formamide, ethylene glycol, dimethylacetamide, and dimethyl sulfoxide) was determined using a dynamic method over the temperature range from 278.15 to 323.15 K. The results indicate that the solubility of acetylcysteine increases with increases in temperature. Furthermore, the solubility of acetylcysteine in alcohols decreases with decreasing polarity. These solubility data were compared with predictions generated using the modified Apelblat equation, the lambda h equation, the Wilson model, and the NRTL model. The modified Apelblat equation generated the most accurate values.
引用
收藏
页码：3435 / 3443
页数：9
相关论文
共 50 条
  • [21] Assessment of solid-liquid equilibrium behavior of naphazoline nitrate in ten pure solvents by molecular simulation and thermodynamic analysis
    Wan, Yameng
    Gao, Xiaoqiang
    Guo, Xiaoxi
    Li, Fanfan
    Cao, Yi
    Li, Yanxun
    JOURNAL OF MOLECULAR LIQUIDS, 2022, 349
  • [22] Solid-Liquid Equilibrium of Isomaltulose in Five Pure Solvents and Four Binary Solvents from (283.15 to 323.15) K
    Song, Shuang
    Guo, Jun
    Qiu, Jingxuan
    Liu, Jinyu
    An, Mengyao
    Yi, Dengjing
    Wang, Peng
    Zhang, Huixuan
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2019, 64 (03): : 963 - 971
  • [23] Solid-liquid phase equilibrium of glyphosate in selected solvents
    Jia, Dongmei
    Wang, Lisheng
    Li, Changhai
    Wang, Xinxin
    FLUID PHASE EQUILIBRIA, 2012, 327 : 1 - 8
  • [24] Solid-liquid equilibrium of terephthalic acid in several solvents
    Ma, PS
    Chen, MM
    CHINESE JOURNAL OF CHEMICAL ENGINEERING, 2003, 11 (03) : 334 - 337
  • [25] Solid-Liquid Equilibrium of Terephthalic Acid in Several Solvents
    马沛生
    陈明鸣
    Chinese Journal of Chemical Engineering, 2003, (03) : 94 - 97
  • [26] Solid-Liquid Phase Equilibrium and the Thermodynamic Correlation of Felodipine Form I in Pure and Mixed Solvents
    Li, Shasha
    Nie, Xiaqing
    Liu, Chao
    Zhou, Danhong
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2022, 67 (02): : 484 - 490
  • [27] Solid-Liquid Equilibrium of Rebaudioside A in Pure and Binary Mixed Solvents at T = (288.15 to 328.15) K
    Asadzadeh, Behnaz
    Zhong, Jialun
    Yan, Weidong
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2018, 63 (11): : 4269 - 4276
  • [28] Determining the solubility and understanding the solid-liquid equilibrium behavior of cyhalothric acid in eleven pure solvents
    Wang, Mengwei
    Liu, Yu
    Du, Shichao
    Zhao, Yanxiao
    Liu, Shiyuan
    Zhou, Lina
    Wu, Songgu
    JOURNAL OF MOLECULAR LIQUIDS, 2020, 300
  • [29] Investigation of solid-liquid equilibrium of stevioside in different pure and binary mix solvents at various temperatures
    Asadzadeh, Behnaz
    Liu, Bingbing
    Yan, Weidong
    CANADIAN JOURNAL OF CHEMISTRY, 2019, 97 (12) : 815 - 823
  • [30] Determination and correlation thermodynamic models for solid-liquid equilibrium of the Nifedipine in pure and mixture organic solvents
    Wu, Gang
    Hu, Yonghong
    Gu, Pengfei
    Yang, Wenge
    Wang, Chunxiao
    Ding, Zhiwen
    Deng, Renlun
    Li, Tao
    Hong, Housheng
    JOURNAL OF CHEMICAL THERMODYNAMICS, 2016, 102 : 333 - 340
12345