Molecular Profiling of Endometrial Cancer From TCGA to Clinical Practice

Molecular classification provides an objective, reproducible frame-work for categorization of endometrial cancers (ECs), informing prog-nosis and selection of therapy. Currently, the uptake of molecular classification, integration in to EC management algorithms, and en-rollment in molecular subtype-specific clinical trials lags behind what it could be. Access to molecular testing is not uniform, and subsequent management (surgical, adjuvant therapy) is unacceptably variable. We are in the midst of a critical landscape change in this disease site, with increasing emphasis on the integration of molecular features in EC care that can potentially improve standard of care globally. This article summarizes the rationale for molecular classification of ECs, strat-egies for implementation in low and high resource settings, and action-able opportunities based on this information.