Structure-affinity relationship study for identifying a blood-brain barrier penetrant selective D3 receptor PET tracer

被引:0
|
作者
Kim, Ho Young [1 ]
Lee, Ji Youn [1 ]
Hsieh, Chia-Ju [1 ]
Hou, Catherine [1 ]
Young, Anthony [1 ]
Li, Shihong [1 ]
Lee, Hsiaoju [1 ]
Mach, Robert [1 ]
机构
[1] Univ Penn, Philadelphia, PA USA
关键词
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
P1404
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model
    Shimomura K.
    Okura T.
    Kato S.
    Couraud P.-O.
    Schermann J.-M.
    Terasaki T.
    Deguchi Y.
    Fluids and Barriers of the CNS, 10 (1)
  • [42] The Novel lncRNA ENST00000530525 Affects ANO1, Contributing to Blood-Brain Barrier Injury in Cultured hCMEC/D3 Cells Under OGD/R Conditions
    Jiang, Wen
    Li, Jie
    Cai, Yuefang
    Liu, Wenchen
    Chen, Mei
    Xu, Xiaoying
    Deng, Minzhen
    Sun, Jingbo
    Zhou, Lihua
    Huang, Yan
    Wu, Shuang
    Cheng, Xiao
    FRONTIERS IN GENETICS, 2022, 13
  • [43] GRID/GOLPE 3D quantitative structure-activity relationship study on a set of benzamides and naphthamides, with affinity for the dopamine D-3 receptor subtype
    Nilsson, J
    Wikstrom, H
    Smilde, A
    Glase, S
    Pugsley, T
    Cruciani, G
    Pastor, M
    Clementi, S
    JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (06) : 833 - 840
  • [44] N′-3-(Trifluoromethyl)phenyl Derivatives of N-Aryl-N′-methylguanidines as Prospective PET Radioligands for the Open Channel of the N-Methyl-D-aspartate (NMDA) Receptor: Synthesis and Structure-Affinity Relationships
    Naumiec, Gregory R.
    Jenko, Kimberley J.
    Zoghbi, Sami S.
    Innis, Robert B.
    Cai, Lisheng
    Pike, Victor W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (24) : 9722 - 9730
  • [45] Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier
    Cabezon, Itsaso
    Auge, Elisabet
    Bosch, Manel
    Beckett, Alison J.
    Prior, Ian A.
    Pelegri, Carme
    Vilaplana, Jordi
    HISTOCHEMISTRY AND CELL BIOLOGY, 2017, 148 (01) : 3 - 12
  • [46] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model
    Ohtsuki, Sumio
    Ikeda, Chiemi
    Uchida, Yasuo
    Sakamoto, Yumi
    Miller, Florence
    Glacial, Fabienne
    Decleves, Xavier
    Scherrmann, Jean-Michel
    Couraud, Pierre-Olivier
    Kubo, Yoshiyuki
    Tachikawa, Masanori
    Terasaki, Tetsuya
    MOLECULAR PHARMACEUTICS, 2013, 10 (01) : 289 - 296
  • [47] Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
    Eigenmann D.E.
    Xue G.
    Kim K.S.
    Moses A.V.
    Hamburger M.
    Oufir M.
    Fluids and Barriers of the CNS, 10 (1)
  • [48] Functional Expression of Organic Cation/carnitine Transporter 2 (OCTN2/SLC22A5) in Human Brain Capillary Endothelial Cell Line hCMEC/D3, a Human Blood-brain Barrier Model
    Okura, Takashi
    Kato, Sayaka
    Deguchi, Yoshiharu
    DRUG METABOLISM AND PHARMACOKINETICS, 2014, 29 (01) : 69 - 74
  • [49] ABC and SLC Transporter Expression and Proton Oligopeptide Transporter (POT) Mediated Permeation across the Human Blood-Brain Barrier Cell Line, hCMEC/D3 (vol 7, pg 1057, 2010)
    Carl, Stephen M.
    Lindley, David J.
    Das, Debanjan
    Couraud, Pierre O.
    Weksler, Babette B.
    Romero, Ignacio
    Mowery, Stephanie A.
    Knipp, Gregory T.
    MOLECULAR PHARMACEUTICS, 2012, 9 (12) : 3606 - 3606
  • [50] Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model
    Qosa, Hisham
    LeVine, Harry, III
    Keller, Jeffrey N.
    Kaddoumi, Amal
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2014, 1842 (09): : 1806 - 1815