Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

被引：15

作者：

Kroese, Tiuri E. ^{[1
,2
]}

van Laarhoven, Hanneke W. M. ^{[67
,68
]}

Schoppman, Sebastian F. ^{[3
]}

Deseyne, Pieter R. A. J. ^{[4
]}

van Cutsem., Eric ^{[5
]}

Haustermans., Karin ^{[6
]}

Nafteux, Philippe. ^{[7
]}

Thomas, Melissa ^{[8
]}

Obermannova, Radka ^{[9
,10
]}

Mortensen, Hanna R. ^{[11
]}

Nordsmark, Marianne ^{[12
]}

Pfeiffer, Per ^{[13
]}

Elme, Anneli ^{[14
]}

Adenis, Antoine ^{[15
]}

Piessen, Guillaume ^{[16
]}

Bruns, Christiane J. ^{[17
]}

Lordick, Florian ^{[18
]}

Gockel, Ines ^{[19
]}

Moehler, Markus ^{[20
]}

Gani, Cihan ^{[21
]}

Liakakos, Theodore ^{[22
]}

Reynolds, John ^{[23
]}

Morganti, Alessio G. ^{[24
,69
]}

Rosati, Riccardo ^{[25
]}

Castoro, Carlo ^{[26
,70
]}

Cellini, Francesco ^{[27
,71
]}

D'Ugo, Domenico ^{[28
]}

Roviello, Franco ^{[29
]}

Bencivenga, Maria ^{[30
]}

de Manzoni, Giovanni ^{[30
]}

Henegouwen, Mark I. van Berge ^{[31
,68
]}

Hulshof, Maarten C. C. M. ^{[32
]}

van Dieren, Jolanda ^{[33
]}

Vollebergh, Marieke ^{[34
]}

van Sandick, Johanna W. ^{[35
]}

Jeene, Paul ^{[36
]}

Muijs, Christel T. ^{[37
]}

Slingerland, Marije ^{[38
]}

Voncken, Francine E. M. ^{[39
]}

Hartgrink, Henk ^{[40
]}

Creemers, Geert-Jan ^{[41
]}

van der Sangen, Maurice J. C. ^{[42
]}

Nieuwenhuijzen, Grard ^{[43
]}

Berbee, Maaike ^{[44
]}

Verheij, Marcel ^{[45
]}

Wijnhoven, Bas ^{[46
]}

V. Beerepoot, Laurens ^{[47
]}

Mohammad, Nadia H. ^{[48
]}

Mook, Stella ^{[2
]}

Ruurda, Jelle P. ^{[1
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Surg, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[3] Univ Vienna, Med Univ Vienna, Dept Surg, Vienna, Austria

[4] Ghent Univ Hosp, Dept Radiat Oncol, Ghent, Belgium

[5] Leuven Univ, KU Leuven, Dept Med Oncol, Leuven, Belgium

[6] Leuven Univ, KU Leuven, Dept Radiat Oncol, Leuven, Belgium

[7] Leuven Univ, KU Leuven, Dept Surg, Leuven, Belgium

[8] AZ Sint Maarten, Dept Radiat Oncol, Mechelen, Sint Maarten

[9] Masaryk Univ, Masaryk Mem Canc Inst, Dept Comprehens Canc Care, Brno, Czech Republic

[10] Masaryk Univ, Fac Med, Brno, Czech Republic

[11] Aarhus Univ, Aarhus Univ Med Ctr, Danish Ctr Particle Therapy, Aarhus, Denmark

[12] Aarhus Univ, Aarhus Univ Med Ctr, Dept Radiat Oncol, Aarhus, Denmark

[13] Univ Odense, Odense Univ Med Ctr, Dept Med Oncol, Odense, Denmark

[14] Tallinn Univ, Tallinn Univ Hosp, Dept Med Oncol, Tallinn, Estonia

[15] Univ Montpellier, Dept Med Oncol, INSERM, IRCM,ICM, Montpellier, France

[16] Univ Lille, CANTHER Canc Heterogene Plast & Resistance Therap, Dept Surg, CNRS,Inserm,CHU Lille,UMR9020,U1277, F-59000 Lille, France

[17] Univ Cologne, Univ Hosp Cologne, Dept Surg, Cologne, Germany

[18] Univ Leipzig, Univ Hosp Leipzig, Dept Med Oncol, Leipzig, Germany

[19] Univ Leipzig, Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany

[20] Johannes Gutenberg Univ Mainz, Dept Med, Johannes Gutenberg Univ Clin, Mainz, Germany

[21] Univ Tubingen, Univ Tubingen Hosp, Dept Radiat Oncol, Tubingen, Germany

[22] Natl & Kapodistrian Univ Athens, Sch Med, Dept Surg, Athens, Greece

[23] Trinity Coll Dublin, St James Hosp, Dept Surg, Dublin, Ireland

[24] IRCCS Azienda Osped Univ Bologna, Dept Radiat Oncol, Bologna, Italy

[25] San Raffaele Vita Salute Univ, Hosp San Raffaele, Dept GI Surg, Milan, Italy

[26] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Milan, Italy

[27] Univ Cattolica Sacro Cuore, Dipartimento Univ Diagnost Immagini Radioterapia, Rome, Italy

[28] Fdn Policlin Univ Agostino Gemelli, Dept Surg, Rome, Italy

[29] Univ Siena, Siena Univ Hosp, Dept Surg, Siena, Italy

[30] Univ Verona, Dept Surg Dent Paediat & Gynaecol, Gen & Upper GI Div, Verona, Italy

[31] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Surg, Amsterdam, Netherlands

[32] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Radiat Oncol, Amsterdam, Netherlands

[33] Netherlands Canc Inst, Dept Gastroenterol, Antoni van Leeuwenhoek, Amsterdam, Netherlands

[34] Netherlands Canc Inst, Dept Med Oncol, Antoni van Leeuwenhoek, Amsterdam, Netherlands

[35] Netherlands Canc Inst, Dept Surg, Antoni van Leeuwenhoek, Amsterdam, Netherlands

[36] Radiotherapiegrp, Dept Radiat Oncol, Deventer, Netherlands

[37] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands

[38] Leiden Univ, Univ Med Ctr Leiden, Dept Med Oncol, Leiden, Netherlands

[39] Leiden Univ, Univ Med Ctr Leiden, Dept Radiat Oncol, Leiden, Netherlands

[40] Leiden Univ, Univ Med Ctr Leiden, Dept Surg, Leiden, Netherlands

[41] Catharina Med Ctr, Dept Med Oncol, Eindhoven, Netherlands

[42] Catharina Med Ctr, Dept Radiat Oncol, Eindhoven, Netherlands

[43] Catharina Med Ctr, Dept Surg, Eindhoven, Netherlands

[44] GROW Sch Oncol & Dev Biol, Dept Radiat Oncol MAASTRO, Maastricht, Netherlands

[45] Radboud Univ Nijmegen Med Ctr, Dept Radiat Oncol, Nijmegen, Netherlands

[46] Univ Rotterdam, Erasmus Univ Med Ctr, Dept Surg, Rotterdam, Netherlands

[47] Elisabeth Tweesteden Ziekenhuis Tilburg, Dept Med Oncol, Tilburg, Netherlands

[48] Univ Utrecht, Univ Med Ctr Utrecht, Dept Med Oncol, Utrecht, Netherlands

[49] Jagiellonian Univ, Coll Med, Dept Surg, Krakow, Poland

[50] Med Univ Lublin, Dept Surg Oncol, Lublin, Poland

来源：

EUROPEAN JOURNAL OF CANCER | 2023年 / 185卷

关键词：

Oesophageal cancer; Gastric cancer; Metastasis; Metastasectomy; Stereotactic body radiotherapy; Oligometastasis; CLINICAL-PRACTICE GUIDELINE; GASTROESOPHAGEAL JUNCTION; SURGICAL RESECTION; PLUS CHEMOTHERAPY; GASTRIC-CANCER; ESOPHAGEAL; ADENOCARCINOMA; NIVOLUMAB; SURVIVAL; CRITERIA;

D O I：

10.1016/j.ejca.2023.02.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesopha-gogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Methods: In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Del-phi study. The consensus finding process consisted of a starting meeting, 2 online Delphi ques-tionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (<50%), fair (50%-75%) or consensus (>75%). Results: A total of 48 experts participated in the starting meeting, both Delphi rounds, and the consensus meeting (overall response rate: 71%). OMD was considered in patients with meta-static oesophagogastric cancer limited to 1 organ with <3 metastases or 1 extra-regional lymph node station (consensus). In addition, OMD was considered in patients without pro-gression at restaging after systemic therapy (consensus). For patients with synchronous or me-tachronous OMD with a disease-free interval <2 years, systemic therapy followed by restaging to consider local treatment was considered as treatment (consensus). For metachronous OMD with a disease-free interval >2 years, either upfront local treatment or systemic treatment fol-lowed by restaging was considered as treatment (fair agreement). Conclusion: The OMEC project has resulted in a multidisciplinary European consensus state -ment for the definition, diagnosis and treatment of oligometastatic oesophagogastric adeno-carcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials. 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：28 / 39

页数：12

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