Efficacy and Safety of Upadacitinib in the Treatment of Chronic Pouchitis, Cuffitis, and Crohn's Disease of the Pouch

被引：10

作者：

Lan, Nan ^{[1
]}

Shen, Bo ^{[2
]}

机构：

[1] Columbia Univ, New York Presbyterian Hosp, Irving Med Ctr, Div Digest & Liver Dis, New York, NY USA

[2] Columbia Univ, New York Presbyterian Hosp, Ctr Inflammatory Bowel Dis, Irving Med Ctr, New York, NY 10027 USA

来源：

ACG CASE REPORTS JOURNAL | 2024年 / 11卷 / 01期

关键词：

Crohn's disease; cuffitis; pouchitis; upadacitinib; MANAGEMENT;

D O I：

10.14309/crj.0000000000001245

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Upadacitinib has shown efficacy in the treatment of moderate-to-severe ulcerative colitis and Crohn's disease (CD). The use of upadacitinib in the treatment of chronic antibiotics-refractory pouchitis (CARP), as well as CD of the pouch, has not been previously reported. We treated a series of 6 patients with CARP or CD of the pouch with a minimal 6 weeks of upadacitinib. The patients showed minimal or no significant improvement in clinical and endoscopic presentations. Our findings warrant further study to validate the efficacy and safety of upadacitinib in the treatment of CARP or CD of the pouch.

引用

页数：4

共 50 条

[21] Efficacy and safety of upadacitinib during induction in Crohn's disease: Real-world experience
Jairath, R.
Zoughlami, A.
Pilote, N.
Afif, W.
Bitton, A.
Wild, G.
Narula, N.
Lakatos, P. L.
Bessissow, T.
JOURNAL OF CROHNS & COLITIS, 2024, 18 : I1337 - I1337
[22] Case Series: Upadacitinib as a Treatment for Crohn's Disease
Thomas, Braden
Thurston, Theresa
Abraham, Bincy
Glassner, Kerri
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2022, 117 : S3 - S4
[23] Upadacitinib for the treatment of moderate to severe Crohn's disease
Kessing, Richard
ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2024, 62 (01): : 25 - 25
[24] Upadacitinib for Crohn's disease
Brierley, Rob
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2022, 7 (08): : 708 - 708
[25] Upadacitinib for Crohn's disease
Baker, Holly
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2020, 5 (04): : 340 - 340
[26] Pathy/Focal Chronic Pouchitis Is Related to Crohn's Disease
Hao, X.
Xin, W.
LABORATORY INVESTIGATION, 2013, 93 : 153A - 153A
[27] Pathy/Focal Chronic Pouchitis Is Related to Crohn's Disease
Hao, X.
Xin, W.
MODERN PATHOLOGY, 2013, 26 : 153A - 153A
[28] Upadacitinib in Crohn's disease
Dignass, Axel
Esters, Philip
Flauaus, Cathrin
EXPERT OPINION ON PHARMACOTHERAPY, 2024, 25 (04) : 359 - 370
[29] Histologic Evaluation of Excised Pouch Specimens in Distinguishing Crohn's Disease of the Pouch (CDP) from Chronic Antibiotic-Refractory Pouchitis (CARP)
DeRoche, T.
Shen, B.
Remzi, F.
Fazio, V.
Bennett, A. E.
Goldblum, J. R.
MODERN PATHOLOGY, 2009, 22 : 127A - 128A
[30] Histologic Evaluation of Excised Pouch Specimens in Distinguishing Crohn's Disease of the Pouch (CDP) from Chronic Antibiotic-Refractory Pouchitis (CARP)
DeRoche, T.
Shen, B.
Remzi, F.
Fazio, V.
Bennett, A. E.
Goldblum, J. R.
LABORATORY INVESTIGATION, 2009, 89 : 127A - 128A

← 1 2 3 4 5 →