Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression

被引：5

作者：

Kramer, Benedikt Alexander ^{[1
]}

Jaehn, Anna ^{[1
]}

Gruetzner, Thea Marianne ^{[1
]}

Hess, Natalie Sarah ^{[1
]}

Bellanti, Amanda ^{[1
]}

Listunova, Lena ^{[1
]}

Hellweg, Rainer ^{[2
,3
,4
]}

Weisbrod, Matthias ^{[1
,5
]}

Ely, Daniela Roesch ^{[1
]}

机构：

[1] Univ Hosp Heidelberg, Ctr Psychosocial Med, Dept Gen Psychiat, Res Grp Neurocognit, Vossstr 4, D-69115 Heidelberg, Germany

[2] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[3] Humboldt Univ, Freie Univ Berlin, Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] SRH Hosp Karlsbad Langensteinbach, Dept Psychiat & Psychotherapy, Guttmannstr 1, D-76307 Karlsbad, Germany

来源：

PSYCHIATRY RESEARCH | 2023年 / 326卷

关键词：

Physical activity; Blood serum; Biomarkers; BDNF;

D O I：

10.1016/j.psychres.2023.115283

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515).

引用

页数：3

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