Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma

被引：0
|
作者：
DeLiberty, Jonathan M.
Stalnecker, Clint A.
Drizyte-Miller, Kristina
Schechter, Elyse G.
Pieper, Noah L.
Yang, Runying
Der, Channing J.
Cox, Adrienne D.
Bryant, Kirsten L.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-4851
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4851
引用
收藏
页数：2
相关论文
共 50 条
  • [41] ERK Inhibition Improves Anti-PD-L1 Immune Checkpoint Blockade in Preclinical Pancreatic Ductal Adenocarcinoma
    Henry, Kelly E.
    Mack, Kyeara N.
    Nagle, Veronica L.
    Cornejo, Mike
    Michel, Adam O.
    Fox, Ian L.
    Davydova, Maria
    Dilling, Thomas R.
    Pillarsetty, Nagavarakishore
    Lewis, Jason S.
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (10) : 2026 - 2034
  • [42] Inhibition of EphB4-ephrinB2 signaling increases efficacy of radiation in pancreatic ductal adenocarcinoma
    Lennon, Shelby
    Bhatia, Shilpa
    Oweida, Ayman
    Sharma, Jaspreet
    Phan, Andy
    Bukkapatnam, Sanjana
    Uyanga, Nomin
    Pitts, Todd
    Leong, Stephen
    Goodman, Karyn
    Raben, David
    Pasquale, Elena
    Martinez-Torrecuadrada, Jorge
    Karam, Sana
    CANCER RESEARCH, 2018, 78 (13)
  • [43] Effect of 3D Matrix Compositions on the Efficacy of EGFR Inhibition in Pancreatic Ductal Adenocarcinoma Cells
    Ki, Chang Seok
    Shih, Han
    Lin, Chien-Chi
    BIOMACROMOLECULES, 2013, 14 (09) : 3017 - 3026
  • [44] Dual MAPK Inhibition Is an Effective Therapeutic Strategy for a Subset of Class II BRAF Mutant Melanomas
    Dankner, Matthew
    Lajoie, Mathieu
    Moldoveanu, Dan
    Tan-Trieu Nguyen
    Savage, Paul
    Rajkumar, Shivshankari
    Huang, Xiu
    Lvova, Maria
    Protopopov, Alexei
    Vuzman, Dana
    Hogg, David
    Park, Morag
    Guiot, Marie-Christine
    Petrecca, Kevin
    Mihalcioiu, Catalin
    Watson, Ian R.
    Siegel, Peter M.
    Rose, April A. N.
    CLINICAL CANCER RESEARCH, 2018, 24 (24) : 6483 - 6494
  • [45] Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism
    Jiang, Honglin
    Courau, Tristan
    Borison, Joseph
    Ritchie, Alexa J.
    Mayer, Aaron T.
    Krummel, Matthew F.
    Collisson, Eric A.
    GASTROENTEROLOGY, 2022, 162 (02) : 590 - +
  • [46] Mechanisms Underlying the Therapeutic Effects of Banzhilian-Baihuasheshecao for Treating Pancreatic Ductal Adenocarcinoma Based on Bioinformatics Strategy
    Zhou, Xianqiang
    Zhang, Tiansong
    LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 21 (13) : 2618 - 2643
  • [47] Significance of Glucose Transporter Type 1 (GLUT-1) Expression in the Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma
    Kurahara, Hiroshi
    Maemura, Kosei
    Mataki, Yuko
    Sakoda, Masahiko
    Iino, Satoshi
    Kawasaki, Yota
    Arigami, Takaaki
    Mori, Shinichiro
    Kijima, Yuko
    Ueno, Shinichi
    Shinchi, Hiroyuki
    Natsugoe, Shoji
    ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (05) : 1432 - 1439
  • [48] Significance of Glucose Transporter Type 1 (GLUT-1) Expression in the Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma
    Hiroshi Kurahara
    Kosei Maemura
    Yuko Mataki
    Masahiko Sakoda
    Satoshi Iino
    Yota Kawasaki
    Takaaki Arigami
    Shinichiro Mori
    Yuko Kijima
    Shinichi Ueno
    Hiroyuki Shinchi
    Shoji Natsugoe
    Annals of Surgical Oncology, 2018, 25 : 1432 - 1439
  • [49] Small molecule inhibitor targeting DDR represents a novel therapeutic strategy for the treatment of pancreatic ductal adenocarcinoma (PDAC)
    Trong Phat Do
    Prochnau, Jack
    Venkata, Prabhakar Pitta
    Khan, Sajid
    Timilsina, Santosh
    Singh, Deepika
    Medina, Daisy
    Amaradhi, Radhika
    Zhou, Daohong
    Hart, Matthew
    McHardy, Stanton
    Rao, Manjeet
    CANCER RESEARCH, 2024, 84 (06)
  • [50] Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/ KRAS/LAMC2/ERK/AKT signaling cascade
    Kirtonia, Anuradha
    Pandya, Gouri
    Singh, Aishwarya
    Kumari, Rachana
    Singh, Bhavana
    Kapoor, Sonia
    Khattar, Ekta
    Pandey, Amit Kumar
    Garg, Manoj
    LIFE SCIENCES, 2025, 362
12345