Prevalence and Factors Associated with Drooling in Parkinson's Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

被引：1

作者：

Santos-Garcia, Diego ^{[1
]}

Fonticoba, Teresa de Deus ^{[2
]}

Bartolome, Carlos Cores ^{[1
]}

Painceiras, Maria J. Feal ^{[1
]}

Iniguez-Alvarado, Maria Cristina ^{[1
]}

Jesus, Silvia ^{[3
,4
]}

Buongiorno, Maria Teresa ^{[5
]}

Planellas, Lluis ^{[6
]}

Cosgaya, Marina ^{[7
]}

Caldentey, Juan Garcia ^{[8
]}

Caballol, Nuria ^{[9
]}

Legarda, Ines ^{[10
]}

Vara, Jorge Hernandez ^{[4
,11
]}

Cabo, Iria ^{[12
]}

Manzanares, Lydia Lopez ^{[13
]}

Aramburu, Isabel Gonzalez ^{[4
,14
]}

Rivera, Maria A. Avila ^{[15
]}

Mayordomo, Victor Gomez ^{[16
]}

Nogueira, Victor ^{[17
]}

Puente, Victor ^{[18
]}

Garcia-Soto, Julio Dotor ^{[19
]}

Borrue, Carmen ^{[20
]}

Vila, Berta Solano ^{[21
]}

Sauco, Maria Alvarez ^{[22
]}

Vela, Lydia ^{[23
]}

Escalante, Sonia ^{[24
]}

Cubo, Esther ^{[25
]}

Padilla, Francisco Carrillo ^{[26
]}

Castrillo, Juan C. Martinez ^{[27
]}

Alonso, Pilar Sanchez ^{[28
]}

Losada, Maria G. Alonso ^{[29
]}

Ariztegui, Nuria Lopez ^{[30
]}

Gaston, Itziar ^{[31
]}

Kulisevsky, Jaime ^{[4
,32
]}

Estrada, Marta Blazquez ^{[33
]}

Seijo, Manuel ^{[12
]}

Martinez, Javier Ruiz ^{[34
]}

Valero, Caridad ^{[35
]}

Kurtis, Monica ^{[36
]}

de Fabregues, Oriol ^{[11
]}

Ardura, Jessica Gonzalez ^{[37
]}

Redondo, Ruben Alonso ^{[38
]}

Ordas, Carlos ^{[39
]}

Diaz, Luis M. L. Lopez ^{[40
]}

McAfee, Darrian ^{[41
]}

Martinez-Martin, Pablo ^{[4
]}

Mir, Pablo ^{[3
,4
]}

机构：

[1] Complejo Hosp Univ A Coruna, La Coruna, Spain

[2] Complejo Hosp Univ Ferrol, La Coruna, Spain

[3] Univ Seville, Hosp Univ Virgen del Rocio, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento,CSIC,Inst Biomed Sev, Seville, Spain

[4] CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Madrid, Spain

[5] Hosp Univ Mutua Terrassa, Barcelona, Spain

[6] Clin Pilar, Barcelona, Spain

[7] Hosp Clin Barcelona, Barcelona, Spain

[8] Ctr Neurol Oms 42, Palma De Mallorca, Spain

[9] Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain

[10] Hosp Univ Son Espases, Palma De Mallorca, Spain

[11] Hosp Univ Vall dHebron, Barcelona, Spain

[12] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain

[13] Hosp Univ La Princesa, Madrid, Spain

[14] Hosp Univ Marques de Valdecilla, Santander, Spain

[15] Hosp Gen Hosp, Consorci Sanitari Integral, Barcelona, Spain

[16] Hosp Univ Clin San Carlos, Madrid, Spain

[17] Hosp Costa, Lugo, Spain

[18] Hosp Mar, Barcelona, Spain

[19] Hosp Univ Virgen Macarena, Seville, Spain

[20] Hosp Infanta Sofia, Madrid, Spain

[21] Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona, Spain

[22] Hosp Gen Univ Elche, Elche, Spain

[23] Fdn Hosp Alcorcon, Madrid, Spain

[24] Hosp Tortosa Verge Cinta HTVC, Tarragona, Spain

[25] Complejo Asistencial Univ Burgos, Burgos, Spain

[26] Hosp Univ Canarias, San Cristobal De La Lagu, Santa Cruz De T, Spain

[27] Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain

[28] Hosp Univ Puerta de Hierro, Madrid, Spain

[29] Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain

[30] Complejo Hosp Toledo, Toledo, Spain

[31] Complejo Hosp Navarra, Pamplona, Spain

[32] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[33] Hosp Univ Cent Asturias, Oviedo, Spain

[34] Hosp Univ Donostia, San Sebastian, Spain

[35] Hosp Arnau Vilanova, Valencia, Spain

[36] Hosp Ruber Int, Madrid, Spain

[37] Hosp Cabuenes, Gijon, Spain

[38] Univ Lucus Augusti HULA, Lugo, Spain

[39] Hosp Rey Juan Carlos, Madrid, Spain

[40] Complejo Hosp Univ Orense CHUO, Orense, Spain

[41] Univ Maryland, Sch Med, Baltimore, MD USA

[42] Fdn Degen, C Juana de Vega 23 2, La Coruna 15004, Spain

来源：

PARKINSONS DISEASE | 2023年 / 2023卷

关键词：

QUALITY-OF-LIFE; NONMOTOR SYMPTOMS; GENDER-DIFFERENCES; RATING-SCALES; IMPACT; SIALORRHEA; DYSPHAGIA; QUESTIONNAIRE; DYSFUNCTION; DIAGNOSIS;

D O I：

10.1155/2023/3104425

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction. Drooling in Parkinson's disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year +/- 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year +/- 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; p < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; p < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR =1.032; p = 0.012), being male (OR = 2.333; p < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR =1.020; p < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR=1.012; p <0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with =2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR =1.121; p = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.

引用

页数：18

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