Post-dialysis fatigue and serum S100B protein in patients on chronic hemodialysis. A pilot study

被引：2
|
作者：
Bossola, Maurizio [1 ,2 ]
Picca, Anna [2 ,3 ]
Marzetti, Emanuele [2 ,3 ]
Pepe, Gilda [2 ,4 ]
Antocicco, Manuela [3 ]
Di Stasio, Enrico [2 ,5 ]
机构：
[1] Policlin Univ Fdn A Gemelli IRCCS, Serv Emodialisi, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Largo A Gemelli 8, I-00168 Rome, Italy
[3] Policlin Univ Fdn A Gemelli IRCCS, Dipartimento Geriatria Neurosci & Ortopedia, Rome, Italy
[4] Policlin Univ Fdn Policlin A Gemelli IRCCS, Div Chirurg Urgenza, Rome, Italy
[5] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Laboratorist & Infettivol, UOC Chim Biochim & Biol Mol Clin, Rome, Italy
来源：
THERAPEUTIC APHERESIS AND DIALYSIS | 2023年 / 27卷 / 03期
关键词：
blood-brain barrier; cytokines; fatigue; hemodialysis; S100B protein; MULTIPLE-SCLEROSIS; SICKNESS; MARKERS; INFLAMMATION; MECHANISMS; EXPRESSION; DEPRESSION; VARIABLES; SYMPTOMS; RECOVERY;
D O I：
10.1111/1744-9987.13944
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background Aim of the present study was to assess whether post-dialysis fatigue (PDF) may be related to pre- or post-dialysis levels of serum S100B protein. Hemodialysis patients (HD) who answered to be fatigued after their hemodialysis sessions when asked: "Do you feel worse after dialysis? if they answered yes" were considered to suffer from PDF. Serum Interleukins (IL-1 beta, IL-6, IL-10), TNF-alpha and S100B were assessed by ELISA kit. Results Thirty HD patients were studied: 22 (73.4%) reported to suffer from PDF. Serum S100B post-dialysis levels (median [IQR] = 17.4 mu g [7.1 to 30.9]) were significantly higher than serum S100B pre-dialysis levels (median [IQR] = 5 mu g [1.4 to 22.1]; p = 0.0001). S100B post-dialysis was significantly higher than S100B pre-dialysis either in patients with PDF or without PDF. Conclusions Pre- and post-dialysis values of serum S100B and its delta did not differ significantly between patients with and without PDF and were not associated with the length of the TIRD in patients on chronic hemodialysis.
引用
收藏
页码：471 / 479
页数：9
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