Characterization of SHP2 phosphatase as a therapeutic target in myeloproliferative neoplasms using an ex vivo bioreactor platform

被引:0
|
作者
Vokalova, L. [1 ,2 ,3 ]
Garcia-Garcia, A. [2 ,3 ]
Reinhardt, E. [2 ,3 ]
Genty, L. [2 ,3 ]
Plantier, E. [2 ,3 ]
Jungius, S. [1 ,2 ,3 ]
Brkic, S. [2 ,3 ]
Rovo, A. [1 ]
Angelillo-Scherrer, A. [4 ,5 ]
Ivan, M. [2 ,3 ]
Meyer, S. C. [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Bern, Dept Biomed Res, Inselspital Bern, Bern, Switzerland
[2] Univ Basel, Basel, Switzerland
[3] Univ Hosp Basel, Dept Biomed, Basel, Switzerland
[4] Bern Univ Hosp, Dept Hematol, Inselspital, Bern, Switzerland
[5] Cent Hematol Lab, Bern, Switzerland
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P433
引用
收藏
页码:223 / 223
页数:1
相关论文
共 50 条
  • [41] Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
    Richards, Cathy E.
    Elamin, Yasir Y.
    Carr, Aoife
    Gately, Kathy
    Rafee, Shereen
    Cremona, Mattia
    Hanrahan, Emer
    Smyth, Robert
    Ryan, Daniel
    Morgan, Ross K.
    Kennedy, Susan
    Hudson, Lance
    Fay, Joanna
    O'Byrne, Kenneth
    Hennessy, Bryan T.
    Toomey, Sinead
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (13)
  • [42] BCL-Xl Represents a Novel Therapeutic Target in Type 2 Mutant Calr-Driven Myeloproliferative Neoplasms
    Nauman, Mirielle
    Vanni, Daniele
    Arellano, Nicole
    Thao Trang Nguyen
    LaBelle, James
    Saygin, Caner
    Catricala, Silvia
    Casetti, Ilaria Carola
    Borsani, Oscar
    Rumi, Elisa
    Pietra, Daniela
    Elf, Shannon
    BLOOD, 2023, 142
  • [43] HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?
    Ramos, Teresa L.
    Ignacio Sanchez-Abarca, Luis
    Redondo, Alba
    Hernandez-Hernandez, Angel
    Almeida, Antonio M.
    Puig, Noemi
    Rodriguez, Concepcion
    Ortega, Rebeca
    Preciado, Silvia
    Rico, Ana
    Muntion, Sandra
    Gonzalez Porras, Jose Ramon
    Del Canizo, Consuelo
    Sanchez-Guijo, Fermin
    ONCOTARGET, 2017, 8 (17) : 28187 - 28202
  • [44] HDAC8 Overexpression in Mesenchymal Stromal Cells from JAK2+ myeloproliferative Neoplasms: A New Therapeutic Target?
    Ramos, Teresa L.
    Ignacio Sanchez-Abarca, Luis
    Beatriz, Roson
    Rodriguez Serrano, Concepcion
    Redondo, Alba
    Ortega, Rebeca
    Hernandez-Hernandez, Angel
    Muntion, Sandra
    Preciado, Silvia
    Ramon Gonzalez-Porras, Jose
    Sanchez-Guijo, Fermin
    Del Canizo, Consuelo
    BLOOD, 2015, 126 (23)
  • [45] Characterization of two distinct inhibitory mechanisms by targeting erbB kinase and Shp2 phosphatase function in glioblastoma cells: Implications for EGFR-targeted therapies
    Zhan, Y
    O'Rourke, DM
    NEURO-ONCOLOGY, 2004, 6 (04) : 324 - 324
  • [46] Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
    Quintas-Cardama, Alfonso
    Vaddi, Kris
    Liu, Phillip
    Manshouri, Taghi
    Li, Jun
    Scherle, Peggy A.
    Caulder, Eian
    Wen, Xiaoming
    Li, Yanlong
    Waeltz, Paul
    Rupar, Mark
    Burn, Timothy
    Lo, Yvonne
    Kelley, Jennifer
    Covington, Maryanne
    Shepard, Stacey
    Rodgers, James D.
    Haley, Patrick
    Kantarjian, Hagop
    Fridman, Jordan S.
    Verstovsek, Srdan
    BLOOD, 2010, 115 (15) : 3109 - 3117
  • [47] Editorial for special issue—human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease
    Cynthia J. Koziol-White
    Reynold A. Panettieri Jr.
    Respiratory Research, 25
  • [48] 3D-EXpress - an ex vivo platform using viably cryopreserved tumoroids for rapid assessment of targeted therapeutic outcomes
    Garrido, Vanessa
    Ataya, Michelle
    Dhanushkodi, Nisha R.
    Currlin, Seth
    Humphrey, Alliyah
    Ehrhart, Jared
    Chakraborty, Rikhia
    CANCER RESEARCH, 2024, 84 (06)
  • [49] Editorial for special issue-human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease
    Koziol-White, Cynthia J.
    Panettieri Jr, Reynold A.
    RESPIRATORY RESEARCH, 2024, 25 (01)
  • [50] Hypoxia-inducible factor 1 (HIF-1) is a new therapeutic target in JAK2V617F-positive myeloproliferative neoplasms
    Baumeister, Julian
    Chatain, Nicolas
    Hubrich, Annika
    Maie, Tiago
    Costa, Ivan G.
    Denecke, Bernd
    Han, Lijuan
    Kuestermann, Caroline
    Sontag, Stephanie
    Sere, Kristin
    Strathmann, Klaus
    Zenke, Martin
    Schuppert, Andreas
    Bruemmendorf, Tim H.
    Kranc, Kamil R.
    Koschmieder, Steffen
    Gezer, Deniz
    LEUKEMIA, 2020, 34 (04) : 1062 - 1074