Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement

被引：2
|
作者：
Zhang, Jian [1 ]
Su, Jia-Yi [2 ]
Liu, Yang-Zi [1 ]
Li, Hao [2 ]
Wang, Quannan [1 ]
Deng, Wei-Ping [1 ,2 ]
机构：
[1] Zhejiang Normal Univ, Coll Chem & Mat Sci, Jinhua 321004, Peoples R China
[2] East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2023年 / 66卷 / 10期
关键词：
palladium; umpolung; allylic alkylation; Pudovik addition; 1,2]-phospha-Brook rearrangement; CARBONYL-COMPOUNDS; ALLYLATION; SUBSTITUTION; IMINES;
D O I：
10.1007/s11426-023-1744-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed. The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way. This cascade reaction proceeds under mild conditions with excellent functional group compatibility. Furthermore, the catalytic asymmetric version has also been explored.
引用
收藏
页码：2810 / 2816
页数：7
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