Herbal/Natural Compounds Resist Hallmarks of Brain Aging: From Molecular Mechanisms to Therapeutic Strategies

被引：6
|
作者：
Qiao, Juhui [1 ]
Wang, Chenxi [1 ]
Chen, Yu [1 ]
Yu, Shuang [2 ]
Liu, Ying [1 ]
Yu, Shiting [1 ]
Jiang, Leilei [1 ]
Jin, Chenrong [1 ]
Wang, Xinran [1 ]
Zhang, Peiguang [3 ]
Zhao, Daqing [1 ]
Wang, Jiawen [1 ,4 ]
Liu, Meichen [1 ]
机构：
[1] Changchun Univ Chinese Med, Northeast Asia Res Inst Tradit Chinese Med, Changchun 130117, Peoples R China
[2] Changchun Univ Chinese Med, Sch Pharm, Changchun 130117, Peoples R China
[3] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, Changchun 130033, Peoples R China
[4] Karolinska Inst, Dept Med, Div Cardiovasc Med, S-17176 Solna, Stockholm, Sweden
来源：
ANTIOXIDANTS | 2023年 / 12卷 / 04期
基金：
中国国家自然科学基金;
关键词：
age-related diseases; herbal; natural compounds; brain; oxidative modifier; KOREAN RED GINSENG; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; 6-HYDROXYDOPAMINE-INDUCED NEUROTOXICITY; MITOCHONDRIAL DYSFUNCTION; ENDOPLASMIC-RETICULUM; ACID PROTECTS; MOUSE MODEL; RAT MODEL;
D O I：
10.3390/antiox12040920
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is a complex process of impaired physiological integrity and function, and is associated with increased risk of cardiovascular disease, diabetes, neurodegeneration, and cancer. The cellular environment of the aging brain exhibits perturbed bioenergetics, impaired adaptive neuroplasticity and flexibility, abnormal neuronal network activity, dysregulated neuronal Ca2+ homeostasis, accumulation of oxidatively modified molecules and organelles, and clear signs of inflammation. These changes make the aging brain susceptible to age-related diseases, such as Alzheimer's and Parkinson's diseases. In recent years, unprecedented advances have been made in the study of aging, especially the effects of herbal/natural compounds on evolutionarily conserved genetic pathways and biological processes. Here, we provide a comprehensive review of the aging process and age-related diseases, and we discuss the molecular mechanisms underlying the therapeutic properties of herbal/natural compounds against the hallmarks of brain aging.
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页数：20
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