Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer

被引：25

作者：

Mcbride, Dillon S. ^{[1
]}

Garushyants, Sofya K. ^{[2
]}

Franks, John ^{[3
]}

Magee, Andrew F. ^{[4
]}

Overend, Steven H. ^{[1
]}

Huey, Devra ^{[1
]}

Williams, Amanda M. ^{[5
]}

Faith, Seth A. ^{[5
]}

Kandeil, Ahmed ^{[3
,6
]}

Trifkovic, Sanja ^{[3
]}

Miller, Lance ^{[3
]}

Jeevan, Trushar ^{[3
]}

Patel, Anami ^{[7
]}

Nolting, Jacqueline M. ^{[1
]}

Tonkovich, Michael J. ^{[8
]}

Genders, J. Tyler ^{[9
]}

Montoney, Andrew J. ^{[9
]}

Kasnyik, Kevin ^{[10
]}

Linder, Timothy J. ^{[11
]}

Bevins, Sarah N. ^{[11
]}

Lenoch, Julianna B. ^{[11
]}

Chandler, Jeffrey C. ^{[12
]}

Deliberto, Thomas J. ^{[13
]}

Koonin, Eugene V. ^{[2
]}

Suchard, Marc A. ^{[4
,14
,15
]}

Lemey, Philippe ^{[16
]}

Webby, Richard J. ^{[3
]}

Nelson, Martha I. ^{[2
]}

Bowman, Andrew S. ^{[1
]}

机构：

[1] Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USA

[2] NIH, Div Intramural Res, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA

[3] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA

[5] Ohio State Univ, Infect Dis Inst, Columbus, OH USA

[6] Natl Res Ctr, Ctr Sci Excellence Influenza Viruses, Giza 12622, Egypt

[7] PathAI Diagnost, Memphis, TN USA

[8] Ohio Dept Nat Resources, Div Wildlife, Athens, OH USA

[9] Wildlife Serv, USDA, Anim & Plant Hlth Inspect Serv, Ft Collins, CO USA

[10] Columbus & Franklin Cty Metro Pk, Westerville, OH USA

[11] Wildlife Serv, USDA, Anim & Plant Hlth Inspect Serv, Natl Wildlife Dis Program, Ft Collins, CO USA

[12] Wildlife Serv, USDA, Anim & Plant Hlth Inspect Serv, Wildlife Dis Diagnost Lab, Ft Collins, CO USA

[13] Wildlife Serv, USDA, Anim & Plant Hlth Inspect Serv, Ft Collins, CO USA

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA USA

[15] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA USA

[16] Katholieke Univ Leuven, Rega Inst, Dept Microbiol Immunol & Transplantat, Leuven, Belgium

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MODEL; DYNAMICS; HAMSTERS;

D O I：

10.1038/s41467-023-40706-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2-8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.

引用

页数：15

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