Photoredox-Catalyzed and Silane-Mediated Hydrofluoromethylation of Unactivated Alkenes with Fluoroiodomethane in Water

被引：9
|
作者：
Hu, Chen-Chen [1 ]
Tong, Chao-Lai [1 ]
Zhang, Yu-Yang [1 ]
Xu, Xiu-Hua [1 ]
Qing, Feng-Ling [1 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 06期
基金：
中国国家自然科学基金;
关键词：
OLEFINS; ACIDS;
D O I：
10.1021/acs.orglett.3c00260
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first hydrofluoromethylation of unactivated alkenes with fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH2F radical toward unactivated alkenes.
引用
收藏
页码：1035 / 1039
页数：5
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