Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives

被引：15
|
作者：
Citarella, Andrea [1 ]
Dimasi, Alessandro [1 ]
Moi, Davide [2 ]
Passarella, Daniele [1 ]
Scala, Angela [3 ]
Piperno, Anna [3 ]
Micale, Nicola [3 ]
机构：
[1] Univ Milan, Dept Chem, Via Golgi 19, I-20133 Milan, Italy
[2] Univ Cagliari, Dept Chem & Geol Sci, SP 8 CA, I-09042 Cagliari, Italy
[3] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno DAlcontres 31, I-98166 Messina, Italy
来源：
BIOMOLECULES | 2023年 / 13卷 / 09期
关键词：
COVID-19; SARS-CoV-2; M-pro; protease inhibitors; coronavirus; peptidomimetics; Paxlovid; nirmatrelvir; DISCOVERY; DESIGN; SARS; PEPTIDOMIMETICS; KETONES;
D O I：
10.3390/biom13091339
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The main protease (M-pro) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of M-pro produces a detrimental effect on the course of the infection, making this target one of the most attractive for the treatment of COVID-19. The current success of the SARS-CoV-2 M-pro inhibitor Nirmatrelvir, the first oral drug for the treatment of severe forms of COVID-19, has further focused the attention of researchers on this important viral target, making the search for new M-pro inhibitors a thriving and exciting field for the development of antiviral drugs active against SARS-CoV-2 and related coronaviruses.
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页数：57
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