Lysine succinylation, the metabolic bridge between cancer and immunity

被引：18

作者：

Shen, Rui ^{[1
]}

Ruan, Hongyun ^{[2
]}

Lin, Shuye ^{[2
]}

Liu, Bin ^{[2
]}

Song, Hang ^{[1
,3
]}

Li, Lu ^{[1
,3
]}

Ma, Teng ^{[2
]}

机构：

[1] Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Hefei 230012, Anhui, Peoples R China

[2] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Canc Res Ctr, Beijing 101149, Peoples R China

[3] Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei 230012, Anhui, Peoples R China

来源：

GENES & DISEASES | 2023年 / 10卷 / 06期

关键词：

Immunity; Mitochondria; SIRT5; Succinyl-CoA; Succinylation; HISTONE; IDENTIFICATION; SIRT5; CROTONYLATION; DESUCCINYLATION; MALONYLATION; DEMETHYLASES; SUCCINATE; TARGETS; GAS41;

D O I：

10.1016/j.gendis.2022.10.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal regulation of lysine succinylation occurs in different cancers, and inhibitors targeting lysine succinylation regulatory enzymes can be used as potential anti-cancer strategies. Therefore, this review focused on the target protein lysine succinylation and its functions in cancer and immunity, in order to provide a reference for finding more potential clinical cancer targets in the future.& COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).

引用

页码：2470 / 2478

页数：9

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