PREDICTION OF ACUTE TOXICITY FOR (Z)-3-(2- PHENYLHYDRAZINYLIDENE)BENZOFURAN-2(3H)-ONE AND ITS DERIVATIVES FOR RATS USING GUSAR PROGRAM

被引：0
|
作者：
Askerova, Ulviyya F. [1 ]
机构：
[1] Baku State Univ, Dept Organ Chem, Baku, Azerbaijan
来源：
NEW MATERIALS COMPOUNDS AND APPLICATIONS | 2023年 / 7卷 / 01期
关键词：
computer prediction LD50; GUSAR program; (Z)-3-(2-phenylhydrazinylidene) benzofuran-2(3H)-one derivatives;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The value of half-lethal doses (LD50) for rodents is a necessary stage of preclinical experimental studies for compounds supposedly having a certain physiological activity. The GUSAR (General Unrestricted Structure-Activity Relationships) computer program is used to determine the LD50 value for the 4 methods of substance administration. A prediction of the LD50 value for (Z)-3-(2-phenylhydrazinylidene)benzofuran-2(3H)-one and its derivatives was gained, and thus the possibilities of computer prediction for acute toxicity were shown.
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页码：50 / 56
页数：7
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