Guided Isolation of New Cytotoxic Cassane Diterpenoids from Caesalpinia sappan

被引：6
|
作者：
Jin, Yue [1 ,2 ]
Tong, Zi-Wei [2 ]
Gao, Hui-Yuan [2 ]
Wu, Zhao-Hua [1 ]
机构：
[1] Mudanjiang Med Coll, Dept Pharmacol, Mudanjiang 157011, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Caesalpinia sappan; cassane diterpenoids; guided isolation; molecular networking; cytotoxicity; APOPTOSIS; SEEDS;
D O I：
10.1002/cbdv.202300211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Guided by an MS/MS-based molecular networking, six undescribed cassane diterpenoids and three known ones were isolated and identified from the seeds of Caesalpinia sappan. Their structures were unequivocally elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Cytotoxic evaluation showed that phanginin JA exhibited significant antiproliferative activities against human non-small cell lung cancer (A549) cells with IC50 values of 16.79 +/- 0.83 mu M. Further flow cytometry analysis revealed that phanginin JA could exert apoptotic effect of A549 cells by arresting cell cycle in G0/G1 phase.
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页数：13
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