Cascade Processes Merging Chemical and Enzyme Catalysis

被引：0

作者：

Ascaso-Alegre, Christian ^{[1
]}

Mangas-Sanchez, Juan ^{[1
,2
]}

机构：

[1] CSIC, Inst Chem Synth & Homogeneous Catalysis ISQCH, Pedro Cerbuna 12, Zaragoza 50009, Spain

[2] Aragonese Fdn Res & Dev ARAID, Zaragoza, Spain

来源：

SYNLETT | 2023年 / 34卷 / 05期

关键词：

biocatalysis; organocatalysis; chemoenzymatic cascades; asymmetric synthesis; one-pot; multi-step; PYRROLIDINE-THIOUREA; AMINE-THIOUREA; ORGANOCATALYST; COMBINATION;

D O I：

10.1055/s-0042-1751403

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cascade processes are an attractive strategy to rapidly build molecular complexity and circumvent the need to isolate reaction intermediates, providing higher efficiencies into synthetic routes with lower environmental toll. We have recently developed a new method to synthesise chiral 1,4-nitro alcohols by sequentially combining three transformations in the same reaction vessel via asymmetric C-C bond formation using a chiral thiourea catalyst and a bioreduction process as key steps.

引用

页码：399 / 404

页数：6

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