Stem Cell Transplant in Immune-deficiency-associated Vaccine-derived Poliovirus

被引：0

作者：

Ranchod, Heena ^{[1
,2
,10
]}

Howard, Wayne ^{[1
,2
]}

Roux, Adele ^{[3
]}

van Zyl, Walda ^{[4
]}

Ekermans, Pieter ^{[5
]}

van den Berg, Sylvia ^{[6
]}

Seakamela, Lerato ^{[1
]}

Makua, Koketso ^{[1
]}

Yousif, Mukhlid ^{[1
,7
]}

Sibiya, Rosinah ^{[1
]}

Du Plessis, Heleen ^{[1
]}

Phalane, Emmanuel ^{[1
,7
]}

Mccarthy, Kerrigan ^{[1
]}

Moonsamy, Shelina ^{[1
]}

Reynders, David ^{[8
]}

Hincks, Jeffrey ^{[9
]}

Suchard, Melinda S. ^{[1
,2
]}

du Plessis, Nicolette M. ^{[8
]}

机构：

[1] Natl Inst Communicable Dis, Ctr Vaccines & Immunol, Johannesburg, South Africa

[2] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, Johannesburg, South Africa

[3] Life Groenkloof Hosp, Pretoria, South Africa

[4] Univ Pretoria, Fac Hlth Sci, Dept Med Virol, Natl Hlth Lab Serv,Tshwane Acad Div, Pretoria, South Africa

[5] Ampath Labs, Dept Med Microbiol, Pretoria, South Africa

[6] Ampath Labs, Dept Immunol, Pretoria, South Africa

[7] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Dept Virol, Johannesburg, South Africa

[8] Univ Pretoria, Fac Hlth Sci, Dept Paediat, Pretoria, South Africa

[9] ViroDefense, Chevy Chase, MD USA

[10] Univ Witwatersrand, Wits Med Sch, Dept Chem Pathol, 7 York Rd, ZA-2193 Johannesburg, South Africa

来源：

OPEN FORUM INFECTIOUS DISEASES | 2024年 / 11卷 / 02期

关键词：

acute flaccid paralysis; disseminated BCG; immunodeficiency; intravenous immune globulin; IRIS; iVDPV; pocapavir; polio; poliomyelitis; RAG; SCID; stem cell transplant; transplant; vaccine-associated; vaccine-derived poliovirus; VAPP; IMMUNODEFICIENCY; ENTEROVIRUS; TYPE-3;

D O I：

10.1093/ofid/ofad678

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with severe primary immunodeficiency are at risk for complications from live-attenuated vaccines. Here, we report a case of a vaccine-associated paralytic polio and Bacille Calmette-Guerin disease in a 6-month-old girl with severe combined immunodeficiency resulting from homozygous recombinant activating gene 1 deficiency. The patient was successfully treated with intravenous immunoglobulins and oral pocapavir for poliovirus, and antimycobacterial therapy for regional Bacille Calmette-Guerin disease, allowing stem cell transplant. Following transplantation, poliovirus type 3 with 13 mutations was detected from cerebrospinal fluid but not from stool, indicating ongoing viral evolution in the central nervous system despite pocapavir treatment. Clinical improvement and immune reconstitution allowed the patient to be successfully discharged with no further detection of poliovirus.

引用

页数：5

共 50 条

[21] Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs
Tebbens, Radboud J. Duintjer
Thompson, Kimberly M.
BMC INFECTIOUS DISEASES, 2015, 15
[22] Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs
Radboud J. Duintjer Tebbens
Kimberly M. Thompson
BMC Infectious Diseases, 15
[23] Comprehensive screening for immunodeficiency-associated vaccine-derived poliovirus: an essential oral poliovirus vaccine cessation risk management strategy
Tebbens, R. J. Duintjer
Thompson, K. M.
EPIDEMIOLOGY AND INFECTION, 2017, 145 (02): : 217 - 226
[24] Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children
Anika Singanayagam
Dimitra Klapsa
Shirelle Burton-Fanning
Julian Hand
Thomas Wilton
Laura Stephens
Ryan Mate
Benjamin Shillitoe
Cristina Celma
Mary Slatter
Terry Flood
Robin Gopal
Javier Martin
Maria Zambon
Nature Communications, 14
[25] Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children
Singanayagam, Anika
Klapsa, Dimitra
Burton-Fanning, Shirelle
Hand, Julian
Wilton, Thomas
Stephens, Laura
Mate, Ryan
Shillitoe, Benjamin
Celma, Cristina
Slatter, Mary
Flood, Terry
Gopal, Robin
Martin, Javier
Zambon, Maria
NATURE COMMUNICATIONS, 2023, 14 (01)
[26] Wild and vaccine-derived poliovirus circulation, and implications for polio eradication
Lopalco, P. L.
EPIDEMIOLOGY AND INFECTION, 2017, 145 (03): : 413 - 419
[27] Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001
Shimizu, H
Thorley, B
Paladin, FJ
Brussen, KA
Stambos, V
Yuen, L
Utama, A
Tano, Y
Arita, M
Yoshida, H
Yoneyama, T
Benegas, A
Roesel, S
Pallansch, M
Kew, O
Miyamura, T
JOURNAL OF VIROLOGY, 2004, 78 (24) : 13512 - 13521
[28] Two Cases of Vaccine-Derived Poliovirus Infection in an Oncology Ward
Schubert, Axel
Boettcher, Sindy
Eis-Huebinger, Anna M.
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (13): : 1296 - 1298
[29] Vaccine-derived poliovirus type 3 emergence in Guinea, 2024
Faye, Martin
Ndiaye, Ndack
Kouadjo, Etienne Kouame
Camara, Seydou Albert
Solano, Sekou
Kebe, Ousmane
Nestor, Niouma
Modibo, Balkissa
Keita, Daman
Diakite, Bangaly
Sidibe, Kankou
Kande, Moctar
Landoh, Dadja Essoya
Sylla, Mohamed
Sow, Sadou
Dosseh, Annick
Chia, Julius Ebua
Diop, Ousmane
Sow, Abdourahmane
Dia, Ndongo
Sall, Amadou Alpha
Cisse, Gassim
Faye, Ousmane
Anfumbom, Kfuthwah
Kipela, Jean Marie
LANCET INFECTIOUS DISEASES, 2025, 25 (03): : e131 - e132
[30] Reversion of neurovirulent mutations, recombination and high intra-host diversity in vaccine-derived poliovirus excreted by patients with primary immune deficiency
Ben Salem, Imene
Khemiri, Haifa
Drechsel, Oliver
Arbi, Marwa
Boettcher, Sindy
Mekki, Najla
Ben Fraj, Ilhem
Souiai, Oussama
Yahyaoui, Mahrez
Ben Farhat, Essia
Meddeb, Zina
Touzi, Henda
Ben Mustapha, Imene
Benkahla, Alia
Ouederni, Monia
Barbouche, Mohamed-R.
Diedrich, Sabine
Triki, Henda
Haddad-Boubaker, Sondes
JOURNAL OF MEDICAL VIROLOGY, 2024, 96 (09)

← 1 2 3 4 5 →