[1] Ctr Hosp Univ Angers, Serv Gynecol Obstet, 4 rue Larrey, F-49933 Angers 9, France
[2] Ctr Hosp Univ Angers, Ecole Sages Femmes, 4 rue Larrey, F-49933 Angers 9, France
[3] Ctr Hosp Univ Angers, Dept Pneumol, Unite Coordinat Tabacol, 4 rue Larrey, F-49933 Angers 9, France
[4] UFR Sante, Equipe Ester, Irset, Inserm UMR 1085,Dept Med, Rue Haute Reculee, F-49045 Angers, France
[5] UNIV Angers, MINT, UMR INSERM 1066, UMR CNRS 6021,Micro & Nano Med Translationnelles, Angers, France
[6] Angers Univ Hosp, Methodol & Biostat Dept, Delegat Clin Res & Innovat, F-49100 Angers, France