The Effects of Angelica ternata Extract from Kyrgyzstan on the Formation of Candida albicans ATCC 10231 Biofilms

被引:2
|
作者
Sachivkina, Nadezhda [1 ]
Karamyan, Arfenya [1 ]
Semenova, Valentina [1 ]
Ignatiev, Aleksej [1 ]
Abdurasulov, Abdugani [2 ]
Muratova, Rakhima [2 ]
Emilbekova, Dinara [2 ]
Ermatova, Venera [2 ]
Risvanli, Ali [3 ]
Salykov, Ruslan [3 ]
Ibragimova, Alfia [1 ]
Neborak, Ekaterina [1 ]
机构
[1] RUDN Univ, Moscow 117198, Russia
[2] Osh State Univ, Osh 723500, Kyrgyzstan
[3] Kyrgyz Turkish Manas Univ, Bishkek 720044, Kyrgyzstan
来源
APPLIED SCIENCES-BASEL | 2023年 / 13卷 / 21期
关键词
Candida albicans; biofilms; extracellular matrix; Angelica ternate; flavonoids; SINENSIS;
D O I
10.3390/app132112042
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The therapeutic potential of Angelica ternata extract was tested against biofilm-associated fungi Candida albicans. Such an extract with a 1.896 +/- 0.071% per 1 mL rutin content of flavonoids can reliably suppress the formation of biofilms of pathogenic yeast-like fungi up to 76.6%. The herbal medicine has a significant effect on the initiation, adhesion, and development of biofilms. If the extract is added to a developed biofilm, it has a significant effect on the matrix. As a result, the "glue" between the cells is washed out and they are more easily washed away from the well of the microplate to which they are attached. In this case, the optical density of the biofilm is halved (50.5%).
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页数:13
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