Ureteral Obstruction Promotes Ureteral Inflammation and Fibrosis

被引：14

作者：

Reicherz, Alina ^{[1
,2
]}

Eltit, Felipe ^{[3
]}

Almutairi, Khaled ^{[1
,4
,5
]}

Mojtahedzadeh, Bita ^{[3
]}

Herout, Roman ^{[1
,6
]}

Chew, Ben ^{[1
]}

Cox, Michael ^{[3
]}

Lange, Dirk ^{[1
]}

机构：

[1] Univ British Columbia, Stone Ctr Vancouver Gen Hosp, Dept Urol Sci, Vancouver, BC, Canada

[2] Ruhr Univ Bochum, Marien Hosp Herne, Dept Urol, Herne, Germany

[3] Univ British Columbia, Vacnouver Prostate Ctr, Dept Urol Sci, Vancouver, BC, Canada

[4] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Appl Med Sci, Jeddah, Saudi Arabia

[5] King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia

[6] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Urol, Dresden, Germany

来源：

EUROPEAN UROLOGY FOCUS | 2023年 / 9卷 / 02期

关键词：

Urolithiasis; Hydronephrosis; Hydroureter; Kidney disease; Peristalsis; Cytokines; Matrix metalloproteinase; CYCLOOXYGENASE-2; EXPRESSION; POLARIZATION;

D O I：

10.1016/j.euf.2022.09.014

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Patient summary: Here, we studied in more detail the way the ureter responds to being blocked. We conclude that a strong immune response is activated by the blockage, leading to changes in the structure of the ureter possibly impacting function, which may not be reversible. This immune response also spreads to the opposite ureter, possibly allowing it to change its function to compensate for the reduced functionality of the blocked (c) 2022 European Association of Urology. Published by Elsevier B.V. All rights reserved.

引用

页码：371 / 380

页数：10

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