An overview of mycetoma and its diagnostic dilemma: Time to move on to advanced techniques

被引:5
|
作者
Husain, Uneza [1 ]
Verma, Parul [2 ]
Suvirya, Swastika [2 ]
Priyadarshi, Ketan [3 ]
Gupta, Prashant [4 ]
机构
[1] Post Grad Inst Med Educ & Res, Dept Microbiol, Chandigarh, India
[2] King Georges Med Univ, Dept Dermatol Venereol & Leprosy, Lucknow, Uttar Pradesh, India
[3] Jawaharlal Inst Postgrad Med Educ & Res, Dept Microbiol, Pondicherry, India
[4] King Georges Med Univ, Dept Microbiol, Lucknow, Uttar Pradesh, India
关键词
Mycetoma; laboratory diagnosis; MALDI-TOF; PCR; rolling circle amplification; loop-mediated isothermal amplification; recombinase polymerase amplification; DESORPTION IONIZATION-TIME; BLACK-GRAIN MYCETOMA; MADURELLA-MYCETOMATIS; MASS-SPECTROMETRY; IDENTIFICATION; FOOT;
D O I
10.25259/IJDVL_615_2021
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The neglected tropical disease mycetoma can become extremely devastating, and can be caused both by fungi and bacteria; these are popularly known as eumycetoma and actinomycetoma respectively. The classical triad of the disease is subcutaneous swelling, multiple discharging sinuses and the presence of macroscopic granules. The present study aims to highlight the existing diagnostic modalities and the need to incorporate newer and more advanced laboratory techniques like pan fungal/pan bacterial 16S rRNA gene polymerase chain reaction (PCR) and sequencing, Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS), rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP) and recombinase polymerase amplification (RPA). It is important for the medical team to be aware of the various diagnostic options (both existing and future), so that diagnosis of such a debilitating disease is never missed, both by clinicians and microbiologists/pathologists. The newer diagnostic methods discussed in this article will help in rapid, accurate diagnosis thus facilitating early treatment initiation, and decreasing the overall morbidity of the disease. In the Indian context, newer technologies need to be made available more widely. Making clinicians aware and promoting research and development in mycetoma diagnostics is the need of the hour.
引用
收藏
页码:12 / 17
页数:6
相关论文
共 50 条
  • [31] Phosphaturic mesenchymal tumour: A rare tumour & its diagnostic dilemma
    Srivastava, Sudhir Kumar
    Raj, Aditya
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2020, 152 (07) : 222 - 223
  • [32] It Is Time to Resolve the Dilemma and Move Away From Using Drains in Primary Breast Augmentation
    Montemurro, Paolo
    Gupta, Tarush
    AESTHETIC SURGERY JOURNAL OPEN FORUM, 2023, 5
  • [33] Omental Torsion and Infarction: A Diagnostic Dilemma and Its Laparoscopic Management
    Sasmal, Prakash K.
    Tantia, Om
    Patle, Nirmal
    Khanna, Shashi
    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES, 2010, 20 (03): : 225 - 229
  • [34] The Choice of Invasive Diagnostic Techniques in Advanced Lung Cancer
    Turk, Figen
    Yuncu, Gokhan
    Atinkaya, Cansel
    Semerkant, Tolga
    Ozturk, Gokhan
    Ekinci, Yasin
    THORACIC AND CARDIOVASCULAR SURGEON, 2014, 62 (02): : 97 - 102
  • [35] Special Issue on "Advanced Combustion and Combustion Diagnostic Techniques"
    Wang, Zhihua
    PROCESSES, 2023, 11 (04)
  • [36] Legal evidence and advanced computing techniques for combatting crime: an overview
    Nissan, Ephraim
    INFORMATION & COMMUNICATIONS TECHNOLOGY LAW, 2013, 22 (03) : 213 - 250
  • [37] An Overview of the Advanced Nonintrusive Measurement Techniques in Hypersonic Flow Field
    ZHAO Xuejun
    XIANG Xingju
    MA Yuanhong
    WANG Hongwei
    AerospaceChina, 2017, 18 (04) : 26 - 32
  • [38] ISSCC 2019 Session 30 Overview: Advanced Wireline Techniques
    Digest of Technical Papers - IEEE International Solid-State Circuits Conference, 2019, 2019-February : 472 - 473
  • [39] Chronic Total Occlusions: Patient Selection and Overview of Advanced Techniques
    Garcia, Santiago
    Abdullah, Shuaib
    Banerjee, Subhash
    Brilakis, Emmanouil S.
    CURRENT CARDIOLOGY REPORTS, 2013, 15 (02)
  • [40] Turbine blade wear and damage - An overview of advanced characterization techniques
    Schlobohm, Jochen
    Bruchwald, Oliver
    Frackowiak, Wojciech
    Li, Yinan
    Kaestner, Markus
    Poesch, Andreas
    Reimche, Wilfried
    Reithmeier, Eduard
    Maier, Hans Juergen
    MATERIALS TESTING, 2016, 58 (05) : 389 - 394