High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor

被引：3

作者：

Aoki, Takahiro ^{[1
,18
]}

Shiba, Norio ^{[2
]}

Tsujimoto, Shinichi ^{[2
]}

Yamato, Genki ^{[3
]}

Hara, Yusuke ^{[3
]}

Kato, Shota ^{[4
]}

Yoshida, Kenichi ^{[5
]}

Ogawa, Seishi ^{[6
,7
,8
]}

Hayashi, Yasuhide ^{[9
]}

Iwamoto, Shotaro ^{[10
]}

Taki, Tomohiko ^{[11
]}

Shimada, Akira ^{[12
]}

Iijima-Yamashita, Yuka ^{[13
]}

Horibe, Keizo ^{[13
]}

Tawa, Akio ^{[14
]}

Taga, Takashi ^{[15
]}

Adachi, Souichi ^{[16
]}

Tomizawa, Daisuke ^{[17
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Pediat, Yokohama, Japan

[3] Gunma Univ, Grad Sch Med, Dept Pediat, Maebashi, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Pediat, Tokyo, Japan

[5] Natl Canc Ctr, Div Canc Evolut, Tokyo, Japan

[6] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[7] Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto, Japan

[8] Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med, Stockholm, Sweden

[9] Jobu Univ, Inst Physiol & Med, Takasaki, Japan

[10] Mie Univ, Dept Pediat, Tsu, Japan

[11] Kyorin Univ, Fac Hlth Sci, Dept Med Technol, Mitaka, Japan

[12] Jichi Med Univ, Dept Pediat, Shimotsuke, Japan

[13] NHO Nagoya Med Ctr, Clin Res Ctr, Nagoya, Japan

[14] Higashiosaka Aramoto Heiwa Clin, Higashiosaka, Japan

[15] Shiga Univ Med Sci, Dept Pediat, Shiga, Japan

[16] Kyoto Univ, Dept Human Hlth Sci, Kyoto, Japan

[17] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Div Leukemia & Lymphoma, Tokyo, Japan

[18] Chiba Univ, Grad Sch Med, Dept Pediat, 1 8 1 Inohana,Chuo Ku, Chiba 2608670, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2024年 / 71卷 / 02期

基金：

日本学术振兴会;

关键词：

acute myeloid leukemia; CD25; children; leukemic stem cells; RNA sequencing; CD25; EXPRESSION; FAILURE; RELAPSE; TRIAL;

D O I：

10.1002/pbc.30803

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical prevalence and significance of CD25 expression in pediatric AML are unknown. High IL2RA/CD25 expression in pediatric AML showed a stem cell-like phenotype, and elevated CD25 expression was associated with lower overall survival (p < .001) and event-free survival (p < .001) in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. This finding was reproduced in AML without a core-binding factor in the Children's Oncology Group study cohort. High CD25 expression has prognostic significance in pediatric AML.

引用

页数：5

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