High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor

被引：3

作者：

Aoki, Takahiro ^{[1
,18
]}

Shiba, Norio ^{[2
]}

Tsujimoto, Shinichi ^{[2
]}

Yamato, Genki ^{[3
]}

Hara, Yusuke ^{[3
]}

Kato, Shota ^{[4
]}

Yoshida, Kenichi ^{[5
]}

Ogawa, Seishi ^{[6
,7
,8
]}

Hayashi, Yasuhide ^{[9
]}

Iwamoto, Shotaro ^{[10
]}

Taki, Tomohiko ^{[11
]}

Shimada, Akira ^{[12
]}

Iijima-Yamashita, Yuka ^{[13
]}

Horibe, Keizo ^{[13
]}

Tawa, Akio ^{[14
]}

Taga, Takashi ^{[15
]}

Adachi, Souichi ^{[16
]}

Tomizawa, Daisuke ^{[17
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Pediat, Yokohama, Japan

[3] Gunma Univ, Grad Sch Med, Dept Pediat, Maebashi, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Pediat, Tokyo, Japan

[5] Natl Canc Ctr, Div Canc Evolut, Tokyo, Japan

[6] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[7] Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto, Japan

[8] Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med, Stockholm, Sweden

[9] Jobu Univ, Inst Physiol & Med, Takasaki, Japan

[10] Mie Univ, Dept Pediat, Tsu, Japan

[11] Kyorin Univ, Fac Hlth Sci, Dept Med Technol, Mitaka, Japan

[12] Jichi Med Univ, Dept Pediat, Shimotsuke, Japan

[13] NHO Nagoya Med Ctr, Clin Res Ctr, Nagoya, Japan

[14] Higashiosaka Aramoto Heiwa Clin, Higashiosaka, Japan

[15] Shiga Univ Med Sci, Dept Pediat, Shiga, Japan

[16] Kyoto Univ, Dept Human Hlth Sci, Kyoto, Japan

[17] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Div Leukemia & Lymphoma, Tokyo, Japan

[18] Chiba Univ, Grad Sch Med, Dept Pediat, 1 8 1 Inohana,Chuo Ku, Chiba 2608670, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2024年 / 71卷 / 02期

基金：

日本学术振兴会;

关键词：

acute myeloid leukemia; CD25; children; leukemic stem cells; RNA sequencing; CD25; EXPRESSION; FAILURE; RELAPSE; TRIAL;

D O I：

10.1002/pbc.30803

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical prevalence and significance of CD25 expression in pediatric AML are unknown. High IL2RA/CD25 expression in pediatric AML showed a stem cell-like phenotype, and elevated CD25 expression was associated with lower overall survival (p < .001) and event-free survival (p < .001) in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. This finding was reproduced in AML without a core-binding factor in the Children's Oncology Group study cohort. High CD25 expression has prognostic significance in pediatric AML.

引用

页数：5

共 50 条

[1] High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia
Du, Wen
He, Jing
Zhou, Wei
Shu, Simin
Li, Juan
Liu, Wei
Deng, Yun
Lu, Cong
Lin, Shengyan
Ma, Yaokun
He, Yanli
Zheng, Jine
Zhu, Jiang
Bai, Lijuan
Li, Xiaoqing
Yao, Junxia
Hu, Dan
Gu, Shengqing
Li, Huiyu
Guo, Anyuan
Huang, Shiang
Feng, Xiaolan
Hu, Dong
JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (1)
[2] High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia
Wen Du
Jing He
Wei Zhou
Simin Shu
Juan Li
Wei Liu
Yun Deng
Cong Lu
Shengyan Lin
Yaokun Ma
Yanli He
Jine Zheng
Jiang Zhu
Lijuan Bai
Xiaoqing Li
Junxia Yao
Dan Hu
Shengqing Gu
Huiyu Li
Anyuan Guo
Shiang Huang
Xiaolan Feng
Dong Hu
Journal of Translational Medicine, 17
[3] Prognostic Factor Analysis in Core-Binding Factor-positive Acute Myeloid Leukemia
Jung, Hyun Ae
Maeng, Chi Hoon
Park, Silvia
Kim, Seok Jin
Kim, Kihyun
Jang, Jun Ho
Jung, Chul Won
ANTICANCER RESEARCH, 2014, 34 (02) : 1037 - 1045
[4] CLINICAL OUTCOME OF CD25 HIGH PEDIATRIC ACUTE MYELOID LEUKEMIA
Aoki, Takahiro
Shiba, Norio
Tsujimoto, Shinichi
Yoshida, Kenichi
Ogawa, Seishi
Hayashi, Yasuhide
Tawa, Akio
Taga, Takashi
Adachi, Souichi
Tomizawa, Daisuke
PEDIATRIC BLOOD & CANCER, 2022, 69
[5] CD25 Expression as a Risk Factor in Patients with Acute Myeloid Leukemia
Iskrou, I.
Uss, A.
Lendzina, I.
ANNALS OF HEMATOLOGY, 2017, 96 : S64 - S65
[6] The prognostic significance of CD25 & CD123 expression in acute myeloid leukemia
Thasneem, F. T.
Narayanan, G.
Nair, S. G.
Purushothaman, P. N.
Thambi, S. M.
Jayasudha, A. V.
Km, J. Krishna
ANNALS OF ONCOLOGY, 2024, 35
[7] CD25 as an adverse prognostic factor in elderly patients with acute myeloid leukemia
Fujiwara, Shin-ichiro
Muroi, Kazuo
Yamamoto, Chihiro
Hatano, Kaoru
Okazuka, Kiyoshi
Sato, Kazuya
Oh, Iekuni
Ohmine, Ken
Suzuki, Takahiro
Ozawa, Keiya
HEMATOLOGY, 2017, 22 (06) : 347 - 353
[8] IL2RA Promotes Aggressiveness and Stem Cell-Related Properties of Acute Myeloid Leukemia
Nguyen, Chi Huu
Schlerka, Angela
Grandits, Alexander M.
Koller, Elisabeth
van der Kouwe, Emiel
Vassiliou, George S.
Staber, Philipp B.
Heller, Gerwin
Wieser, Rotraud
CANCER RESEARCH, 2020, 80 (20) : 4527 - 4539
[9] Leukemia stem cell markers (CD 123 and CD25) are poor prognostic markers in patients with adult acute myeloid leukemia
Farweez, Botheina A. T.
Hashem, Azza E.
Elsalakawy, Walaa A.
EGYPTIAN JOURNAL OF HAEMATOLOGY, 2019, 44 (04): : 208 - 217
[10] CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia
Lee, Jae-Woong
Chen, Zhengshan
Geng, Huimin
Xiao, Gang
Park, Eugene
Parekh, Samir
Kornblau, Steven M.
Melnick, Ari
Abbas, Abul
Paietta, Elisabeth
Muschen, Markus
BLOOD, 2015, 126 (23)

← 1 2 3 4 5 →