The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies

被引：21
|
作者：
Wang, Weiyuan [1 ]
McDonald, Melanie Cristina Lopez [1 ]
Kim, Christine [1 ]
Ma, Mirielle [1 ]
Pan, Zetao [1 ]
Kaufmann, Charlotte [1 ]
Frank, David A. [1 ]
机构：
[1] Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Sch Med, Atlanta, GA 30307 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
cancer; oncology; transcription factors; signal transduction; tumor immunology; protein phosphorylation; RECEPTOR SIGNALING PATHWAYS; IFN-GAMMA; CONSTITUTIVE ACTIVATION; INTERFERON-GAMMA; JAK-STAT; IMMUNE-RESPONSES; GROWTH-FACTOR; CELLS; GENE; TRANSCRIPTION;
D O I：
10.3389/fimmu.2023.1265818
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity.
引用
收藏
页数：12
相关论文
共 50 条
  • [31] Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
    C Gordziel
    J Bratsch
    R Moriggl
    T Knösel
    K Friedrich
    British Journal of Cancer, 2013, 109 : 138 - 146
  • [32] STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
    Liu, Zhaoyong
    Zhang, Ying
    Chen, Yelong
    Lin, Youbin
    Lin, Zhen
    Wang, Hu
    CANCER MANAGEMENT AND RESEARCH, 2018, 10 : 6517 - 6523
  • [33] Constitutive activation of Stat3: Biology and therapeutic implications
    Hua, Yu
    TUMOR BIOLOGY, 2006, 27
  • [34] STAT1 and STAT3 activation during the course of experimental arthritis.
    de Hooge, ASK
    van de Loo, FAJ
    Kolbe, T
    Mueller, M
    Levy, DE
    Bennink, M
    Arntzl, OJ
    van den Berg, WB
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S250 - S250
  • [35] IL-10 INDUCES STAT1 AND STAT3 ACTIVATION IN CELLS
    WEBERNORDT, RM
    GREENLUND, AC
    DARNELL, JE
    SCHREIBER, RD
    BLOOD, 1994, 84 (10) : A223 - A223
  • [36] Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3
    Friedrich, Karlheinz
    Dolznig, Helmut
    Han, Xiaonan
    Moriggl, Richard
    BIOSCIENCE TRENDS, 2017, 11 (01) : 1 - 8
  • [37] Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells
    Chung, Seyung S.
    Adekoya, Debbie
    Enenmoh, Ikechukwu
    Clarke, Orette
    Wang, Piwen
    Sarkyssian, Marianna
    Wu, Yong
    Vadgama, Jaydutt V.
    ANTICANCER RESEARCH, 2017, 37 (02) : 445 - 453
  • [38] Differential expression of iL10r2, STAT1 and STAT3 in colorectal cancer
    Movadat, Oliver
    Gruber, Sabine G.
    Agu, Chukwuma A.
    Marian, Brigitte
    Wrba, Friedrich
    Gasche, Christoph
    GASTROENTEROLOGY, 2008, 134 (04) : A384 - A384
  • [39] Diverse roles of STAT3 signaling in cancer
    Yu, Hua
    Jove, Richard
    CYTOKINE, 2008, 43 (03) : 276 - 276
  • [40] Transcription protein STAT1:: Biology and relation to cancer
    Adamkova, L.
    Souckova, K.
    Kovarik, J.
    FOLIA BIOLOGICA, 2007, 53 (01) : 1 - 6
12345