Fertility-enhancing effects of inositol & vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis

被引:1
|
作者
Moslehi, Amir Hosein [1 ]
Hoseinpour, Fatemeh [1 ,7 ]
Saber, Amir [2 ,8 ]
Taheri, Maryam Akhavan [3 ,4 ]
Hashemian, Amir Hossein [5 ,6 ]
机构
[1] Razi Univ, Fac Vet Med, Dept Basic Sci, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah, Iran
[3] Kashan Univ Med Sci, Anat Sci Res Ctr, Inst Basic Sci, Kashan, Iran
[4] Kashan Univ Med Sci, Gametogenesis Res Ctr, Kashan, Iran
[5] Kermanshah Univ Med Sci, Hlth Inst, Res Ctr Environm Determinants Hlth RCEDH, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Sch Hlth, Dept Biostat, Kermanshah, Iran
[7] Fac Vet Med, Sheikh E Tousi Blvd, Kermanshah 6715685414, Iran
[8] Sch Nutr Sci & Food Technol, Isar Sq, Kermanshah 6719851552, Iran
关键词
Infertility; Cisplatin; Inositol; Vitamin C; Apoptosis; Oxidative stress; CHEMOTHERAPY; ESTROGEN; INHIBITION; RECEPTORS; DAMAGE; RESVERATROL; MYOINOSITOL; ACTIVATION; MECHANISMS; EXPRESSION;
D O I
10.1016/j.fct.2023.113995
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Cisplatin can lead to infertility due to its negative impact on the uterus and ovaries. This study aimed to explore the effects of Inositol and vitamin C on cisplatin-induced infertility. Forty-eight adult female Wistar rats were divided into eight groups (N = 6) and orally treated for 21 days. The treatments were as follows: negative control (saline), positive control (saline and cisplatin injected into the abdomen on day 15), T1-T3: rats given vitamin C (150 mg/kg), Inositol (420 mg/kg), and vitamin C + Inositol, respectively, along with cisplatin injected into the abdomen on day 15, T4-T6: rats given only vitamin C, Inositol, and vitamin C + Inositol, respectively. Vitamin C and Inositol enhanced cisplatin-induced histopathological improvements in the uterus and ovaries, raising progesterone and estradiol serum levels.Furthermore, the supplements enhanced ESR1 gene expression in the uterus and ovary, reducing uterine and ovarian apoptosis caused by cisplatin through modulation of caspase 3, 8, and Bcl-2 gene levels. These substances decreased ovarian and uterine malondialdehyde levels, boosted total antioxidant capacity and superoxide dismutase, and alleviated oxidative stress. The findings reveal that vitamin C and Inositol shield against cisplatinrelated infertility by reducing oxidative stress and apoptosis in the uterus and ovaries.
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页数:12
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