Combining the best of both worlds: radical-based divergent total synthesis

被引：6
|
作者：
Gennaiou, Kyriaki [1 ]
Kelesidis, Antonios [1 ]
Kourgiantaki, Maria [1 ]
Zografos, Alexandros L. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Organ Chem, Saloniki 54124, Greece
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 19卷
关键词：
biomimetic synthesis; cascades; common scaffold; hydrogen atom transfer; photoredox catalysis; ENT-KAURANE DITERPENOIDS; A-C; NATURAL-PRODUCTS; ALKALOIDS; ANTIBIOTICS; MEROTERPENOIDS; DERIVATIVES; CHEMISTRY; FR901483; OLEFINS;
D O I：
10.3762/bjoc.19.1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mature science, combining the art of the total synthesis of complex natural structures and the practicality of delivering highly diverged lead compounds for biological screening, is the constant aim of the organic chemistry community. Delivering natural lead compounds became easier during the last two decades, with the evolution of green chemistry and the concepts of atom economy and protecting-group-free synthesis dominating the field of total synthesis. In this new era, total synthesis is moving towards natural efficacy by utilizing both the biosynthetic knowledge of divergent synthesis and the latest developments in radical chemistry. This contemporary review highlights recent total syntheses that incorporate the best of both worlds.
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页码：1 / 26
页数：26
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