Palladium-catalyzed enantioselective umpolung allylation of amido-tethered allylic carbonates with isatin-derived ketimines

被引：1

作者：

Wang, Lan ^{[1
,2
]}

Lu, Mengxi ^{[1
,2
]}

Li, Kuan ^{[1
,2
]}

Yang, Sen ^{[1
,2
]}

Wang, Lei ^{[3
]}

Guo, Hongchao ^{[1
,2
]}

机构：

[1] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China

[2] China Agr Univ, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China

[3] Nutrichem Co Ltd, Beijing 102206, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 27期

关键词：

ASYMMETRIC 3+2 CYCLOADDITION; N-2,2,2-TRIFLUOROETHYLISATIN KETIMINES; 1,3-DIPOLAR CYCLOADDITION; REACTIVITY; ARYLATION; IMINES;

D O I：

10.1039/d4cc00060a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed enantioselective umpolung allylation reaction of amido-tethered allyl carbonates with N-2,2,2-trifluoroethylisatin ketimines has been realized herein. The reaction worked well under mild reaction conditions to give various chiral oxindole derivatives in moderate to excellent yields with high enantioselectivities. Notably, this work represents the first Pd-catalyzed asymmetric umpolung allylation reaction of N-2,2,2-trifluoroethylisatin ketimines. A palladium-catalyzed enantioselective umpolung allylation reaction of amido-tethered allyl carbonates with N-2,2,2-trifluoroethylisatin ketimines gave various chiral oxindole derivatives in moderate to high yields with good enantioselectivities.

引用

页码：3729 / 3732

页数：4

共 48 条

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K. N. Gavrilov
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