Ir(III)-Catalyzed Dual C-H Activation of 2-Aryl Phthalazinediones and 3-Aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides for the Construction of Spiro-Fused Cyclic Frameworks

被引：0

作者：

Chary, Devulapally Yogananda ^{[1
,2
]}

Reddy, Minpoor Soumya ^{[1
]}

Ajay, Chidrawar ^{[1
,2
]}

Sridhar, Balasubramanian ^{[3
]}

Reddy, Basi V. Subba ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Fluoro Agrochem, CSIR, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India

[3] Indian Inst Chem Technol, Lab X ray Crystallog, CSIR, Hyderabad 500007, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 05期

关键词：

ANNULATION; 2-ARYLINDAZOLES; HYDROCHLORIDE; ANALOGS; POTENT;

D O I：

10.1021/acs.joc.2c02333

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Ir(III)-catalyzed double C-H activation strategy has been developed for the synthesis of highly rigid spiro frameworks by means of ortho-functionalization of 2-aryl phthalazinediones and 2,3-diphenylcycloprop-2-en-1-ones using the Ir(III)/AgSbF6 catalytic system. Similarly, 3-aryl-2H-benzo[e][1,2,4]thiadiazine-1,1-dioxides undergo smooth cyclization with 2,3diphenylcycloprop-2-en-1-ones to afford a diverse range of spiro compounds in good yields with excellent selectivity. Additionally, 2arylindazoles provide the corresponding chalcone derivatives under similar reaction conditions.

引用

页码：2758 / 2772

页数：15

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