Isolation and structure determination of a new depsipeptide crocapeptin C from the myxobacterium Melittangium boletus

被引：0
|
作者：
Thetsana, Chanaphat [1 ]
Kobayashi, Ryo [2 ]
Manadee, Kanitta [2 ,3 ]
Kodani, Shinya [1 ,2 ,4 ]
机构：
[1] Shizuoka Univ, Grad Sch Sci & Technol, Shizuoka, Japan
[2] Shizuoka Univ, Grad Sch Integrated Sci & Technol, Shizuoka, Japan
[3] Chulalongkorn Univ, Fac Sci, Dept Microbiol, Bangkok, Thailand
[4] Shizuoka Univ, Acad Inst, Coll Agr, Shizuoka, Japan
来源：
NATURAL PRODUCT RESEARCH | 2024年
基金：
日本学术振兴会;
关键词：
Peptide; protease inhibitor; Melittangium boletus; CHYMOTRYPSIN INHIBITOR; MICROCYSTIS SP; CYANOPEPTOLIN; PEPTIDE; STRAINS; GENES; BLOOM;
D O I：
10.1080/14786419.2024.2308719
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new cyclic depsipeptide, crocapeptin C (1), containing 3-amino-6-hydroxy-2-piperidone (Ahp) was isolated from the methanol extract of the myxobacterium Melittangium boletus. The chemical structure of crocapeptin C (1) was determined through NMR and ESI-MS analysis. The stereochemistries of the constituent amino acids in crocapeptin C (1) were determined using the advanced Marfey's method and ROESY spectrum data. Crocapeptin C (1) exhibited potent inhibitory activity against chymotrypsin with an IC50 value of 0.5 mu M. [GRAPHICS]
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页数：7
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