Evaluation of Tp-E interval and Tp-E/Qtc ratios in patients with overt hypothyroidism and subclinical hypothyroidism

- OBJECTIVE: Tp-e interval and Tp-e/QTc are among the new-generation indi-cators used for predicting cardiac arrhythmia and ventricular repolarization. In this study, we aimed to evaluate Tp-e and Tp-e/QTc ratios in patients with overt hypothyroidism and subclin-ical hypothyroid patients. PATIENTS AND METHODS: In this study, a total of 105 patients were included with 35 overt hypothyroidism, 35 subclinical hypothyroidism, and 35 healthy euthyroid patients. The anthro-pometric measurements, laboratory results, and electrocardiographic data of the patients were measured. The groups were compared in terms of Tp-e interval, Tp-e/QT and Tp-e QT/c ratios. RESULTS: When the Tp-e interval and Tp-e/QTc values of the patients were compared, a signifi- cant difference was found (p<0.001). A positive correlation was found between thyroid stimulat-ing hormone (TSH) with Tp-e interval and Tp-e/ QT ratio. CONCLUSIONS: Tp-e interval and Tp-e/QTc duration increased in overt hypothyroidism and subclinical hypothyroidism patients compared to euthyroid patients. We believe that regular use of levothyroxine therapy in overt hypothy-roidism patients will decrease cardiac mortality. Cardiac risk factors should be considered to de-cide on levothyroxine therapy for subclinical hy-pothyroidism patients.