The application of hydrazones and hydrazide-hydrazones in the synthesis of bioactive azetidin-2-one derivatives: A mini review

被引：11
|
作者：
Popiolek, Lukasz [1 ]
机构：
[1] Med Univ Lublin, Fac Pharm, Chair & Dept Organ Chem, 4A Chodzki St, PL-20093 Lublin, Poland
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷
关键词：
Hydrazone; Hydrazide-hydrazone; Azetidin-2-one derivative; Biological activity; Antibacterial activity; Antifungal activity; ANTIBACTERIAL;
D O I：
10.1016/j.biopha.2023.114853
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve as useful intermediates in the synthesis of heterocyclic systems like 1,3-benzothiazin-4-one, 1,3-thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives. The azetidin-2-one derivatives show mainly antibacterial, antitubercular and antifungal activity as well as anti-inflammatory, antioxidant, anticonvulsant and antidepressant activity and activity against Parkinson's disease. This review is focused on the literature reports which consider the synthesis and biological properties of azetidin-2-one derivatives.
引用
收藏
页数：11
相关论文
共 50 条
  • [21] Synthesis, characterization and anticancer activity of novel hydrazide-hydrazones derived from ethyl paraben
    Han, M. Ihsan
    Atalay, Pinar
    Imamoglu, Nalan
    Kucukguzel, S. Guniz
    JOURNAL OF RESEARCH IN PHARMACY, 2020, 24 (03): : 341 - 349
  • [22] Synthesis of Novel Gabapentin Scaffold Derived Hydrazide-hydrazones for Potential Antimicrobial agents and Antioxidants
    Pallapati, Ramya Krishna
    Mutchu, Baby Ramana
    Khandapu, Bala Murali Krishna
    Vanga, Umamaheswara Rao
    Varala, Ravi
    Bollikolla, Hari Babu
    CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY, 2020, 3 (04): : 881 - 888
  • [23] Synthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid
    Popiolek, Lukasz
    Patrejko, Pawel
    Gawronska-Grzywacz, Monika
    Biernasiuk, Anna
    Berecka-Rycerz, Anna
    Natorska-Chomicka, Dorota
    Piatkowska-Chmiel, Iwona
    Gumieniczek, Anna
    Dudka, Jaroslaw
    Wujec, Monika
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 130
  • [24] Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones
    Velezheva, Valeriya
    Brennan, Patrick
    Ivanov, Pavel
    Kornienko, Albert
    Lyubimov, Sergey
    Kazarian, Konstantin
    Nikonenko, Boris
    Majorov, Konstantin
    Apt, Alexander
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (03) : 978 - 985
  • [25] Design, Synthesis, and In Vitro and In Vivo Bioactivity Studies of Hydrazide-Hydrazones of 2,4-Dihydroxybenzoic Acid
    Popiolek, Lukasz
    Gawronska-Grzywacz, Monika
    Dziduch, Aleksandra
    Biernasiuk, Anna
    Piatkowska-Chmiel, Iwona
    Herbet, Mariola
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (24)
  • [26] Synthesis and antimicrobial activity of azetidin-2-one containing pyrazoline derivatives
    Shah, Shailesh H.
    Patel, Pankaj S.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2013, 90 (06) : 863 - 866
  • [27] Synthesis and antimicrobial activity evaluation of new hydrazide-hydrazones derived from 1,2,4-triazole
    Guzeldemirci, Nuray Ulusoy
    Satana, Dilek
    Kucukbasmaci, Omer
    ISTANBUL JOURNAL OF PHARMACY, 2020, 50 (01): : 49 - 53
  • [28] Rational design, synthesis and anti-proliferative evaluation of novel benzosuberone tethered with hydrazide-hydrazones
    Yadagiri, Bandi
    Holagunda, Uma Devi
    Bantu, Rajashaker
    Nagarapu, Lingaiah
    Guguloth, Vijayacharan
    Polepally, Sowjanya
    Jain, Nishanth
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (21) : 5041 - 5044
  • [29] A new series of hydrazide-hydrazones based 2-oxonicotinonitriles as antimicrobial agents: Design, synthesis and antimicrobial evaluation
    El-Sayed, H. A.
    Moustafa, A. H.
    Abd El-Moneim, M.
    Awad, H. M.
    Esmat, A.
    AFINIDAD, 2018, 75 (584) : 305 - 310
  • [30] Synthesis, in-vitro inhibition of cholinesterase and in silico studies of new hydrazide-hydrazones derived from Clopidogrel
    Tok, Fatih
    Celikci, Taner
    Acar, Ahmet Beytullah
    Baltas, Nimet
    Basoglu, Faika
    Karakus, Sevgi
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1314
12345