The application of hydrazones and hydrazide-hydrazones in the synthesis of bioactive azetidin-2-one derivatives: A mini review

被引：11
|
作者：
Popiolek, Lukasz [1 ]
机构：
[1] Med Univ Lublin, Fac Pharm, Chair & Dept Organ Chem, 4A Chodzki St, PL-20093 Lublin, Poland
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷
关键词：
Hydrazone; Hydrazide-hydrazone; Azetidin-2-one derivative; Biological activity; Antibacterial activity; Antifungal activity; ANTIBACTERIAL;
D O I：
10.1016/j.biopha.2023.114853
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve as useful intermediates in the synthesis of heterocyclic systems like 1,3-benzothiazin-4-one, 1,3-thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives. The azetidin-2-one derivatives show mainly antibacterial, antitubercular and antifungal activity as well as anti-inflammatory, antioxidant, anticonvulsant and antidepressant activity and activity against Parkinson's disease. This review is focused on the literature reports which consider the synthesis and biological properties of azetidin-2-one derivatives.
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页数：11
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