Two new β-carboline alkaloids from the roots of Anemone altaica

被引：0
|
作者：
Du, Kun [1 ,2 ]
Zeng, Meng-Nan [1 ]
Wang, Yan-Zhi [1 ,2 ]
Liu, Yu-Fei [1 ]
Feng, Wei-Sheng [2 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
[2] Collaborat Innovat Ctr Chinese Med & Resp Dis Coco, Zhengzhou 450046, Peoples R China
来源：
JOURNAL OF NATURAL MEDICINES | 2023年 / 77卷 / 02期
关键词：
Ranunculaceae; Anemone altaica; beta-carboline alkaloid; Anemonilins A and B;
D O I：
10.1007/s11418-023-01679-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new beta-carboline alkaloids, anemonilins A and B (1-2), and two known beta-carboline alkaloids, flazine (3) and 4-(9H-beta-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS. [GRAPHICS] .
引用
收藏
页码：397 / 402
页数：6
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