A new fluorescent probe based on phenothiazine and 7-nitrobenzofuran for specific detection of GSH

被引：7

作者：

Tu, San ^{[1
]}

Li, Dan ^{[1
]}

Feng, Tingting ^{[1
]}

Le, Yi ^{[1
,2
]}

Yan, Longjia ^{[1
,2
]}

Liu, Li ^{[1
,2
]}

机构：

[1] Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China

[2] Guizhou Engn Lab Synthet Drugs, Guiyang 550025, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2024年 / 1295卷

基金：

中国国家自然科学基金;

关键词：

Phenothiazine; 7-Nitrobenzofurazan; Fluorescent probe; Biothiols; Cell imaging; AGGREGATION-INDUCED EMISSION; FLUOROPHORE; DESIGN; H2S;

D O I：

10.1016/j.molstruc.2023.136583

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Biothiols are significant biomarkers for many diseases. The selective identification of biothiols is very crucial. Herein, we combined phenothiazine and 7-nitrobenzofurazan to form a new fluorescent probe TZ-NBD, due to the difference in response of reactive sulfur species to two fluorophores for distinguishing biothiols specifically. The specificity of TZ-NBD towards biothiols was high and sensitive. Moreover, its detection limit was 0.207 mu M for Glutathione (GSH). Finally, TZ-NBD was successfully applied to GSH imaging in HepG2 cells.

引用

页数：8

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