A new fluorescent probe based on phenothiazine and 7-nitrobenzofuran for specific detection of GSH

被引：7
|
作者：
Tu, San [1 ]
Li, Dan [1 ]
Feng, Tingting [1 ]
Le, Yi [1 ,2 ]
Yan, Longjia [1 ,2 ]
Liu, Li [1 ,2 ]
机构：
[1] Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China
[2] Guizhou Engn Lab Synthet Drugs, Guiyang 550025, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2024年 / 1295卷
基金：
中国国家自然科学基金;
关键词：
Phenothiazine; 7-Nitrobenzofurazan; Fluorescent probe; Biothiols; Cell imaging; AGGREGATION-INDUCED EMISSION; FLUOROPHORE; DESIGN; H2S;
D O I：
10.1016/j.molstruc.2023.136583
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Biothiols are significant biomarkers for many diseases. The selective identification of biothiols is very crucial. Herein, we combined phenothiazine and 7-nitrobenzofurazan to form a new fluorescent probe TZ-NBD, due to the difference in response of reactive sulfur species to two fluorophores for distinguishing biothiols specifically. The specificity of TZ-NBD towards biothiols was high and sensitive. Moreover, its detection limit was 0.207 mu M for Glutathione (GSH). Finally, TZ-NBD was successfully applied to GSH imaging in HepG2 cells.
引用
收藏
页数：8
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