Thalamocortical connectivity and its relationship with symptoms and cognition across the psychosis continuum

被引:11
|
作者
Ramsay, Ian S. [1 ]
Mueller, Bryon [1 ]
Ma, Yizhou [2 ,3 ]
Shen, Chen [2 ]
Sponheim, Scott R. [1 ,4 ]
机构
[1] Univ Minnesota, Sch Med, Dept Psychiat & Behav Sci, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Psychol, Minneapolis, MN USA
[3] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Catonsville, MD 21228 USA
[4] Minneapolis Vet Affairs Healthcare Syst, Minneapolis, MN USA
关键词
Cognition; fMRI; psychosis; symptoms; thalamocortical connectivity; FUNCTIONAL CONNECTIVITY; THALAMIC CONNECTIVITY; MEDIODORSAL THALAMUS; BIPOLAR DISORDER; SALIENCE NETWORK; SCHIZOPHRENIA; DYSCONNECTIVITY; DIMENSIONS; RISK; ABNORMALITIES;
D O I
10.1017/S0033291722002793
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background Coordination between the thalamus and cortex is necessary for efficient processing of sensory information and appears disrupted in schizophrenia. The significance of this disrupted coordination (i.e. thalamocortical dysconnectivity) to the symptoms and cognitive deficits of schizophrenia is unclear. It is also unknown whether similar dysconnectivity is observed in other forms of psychotic psychopathology and associated with familial risk for psychosis. Here we examine the relevance of thalamocortical connectivity to the clinical symptoms and cognition of patients with psychotic psychopathology, their first-degree biological relatives, and a group of healthy controls. Method Patients with a schizophrenia-spectrum diagnosis (N = 100) or bipolar disorder with a history of psychosis (N = 33), their first-degree relatives (N = 73), and a group of healthy controls (N = 43) underwent resting functional MRI in addition to clinical and cognitive assessments as part of the Psychosis Human Connectome Project. A bilateral mediodorsal thalamus seed-based analysis was used to measure thalamocortical connectivity and test for group differences, as well as associations with symptomatology and cognition. Results Reduced connectivity from mediodorsal thalamus to insular, orbitofrontal, and cerebellar regions was seen in schizophrenia. Across groups, greater symptomatology was related to less thalamocortical connectivity to the left middle frontal gyrus, anterior cingulate, right insula, and cerebellum. Poorer cognition was related to less thalamocortical connectivity to bilateral insula. Analyses revealed similar patterns of dysconnectivity across patient groups and their relatives. Conclusions Reduced thalamo-prefrontal-cerebellar and thalamo-insular connectivity may contribute to clinical symptomatology and cognitive deficits in patients with psychosis as well as individuals with familial risk for psychotic psychopathology.
引用
收藏
页码:5582 / 5591
页数:10
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