The synthesis of Fe3O4@SiO2@Pr-N (CH2CH2OH)3 and Fe3O4@SiO2@Pr-N (CH2CH2- OBuSO3H)3 as nanomagnetic catalysts and their application in the synthesis of tetrahydroacenaphtho[1,2-b]indolones and docking studies

The Fe3O4@SiO2@Pr-N (CH2CH2-OBuSO3H)(3) as magnetic nanocatalyst with Fe3O4 core has been synthesized and used in the synthesis of tetrahydroacenaphtho[1,2-b]indolones, which was accomplished through the one-pot four-component reaction of 5,5-dimethyl cyclohexane-1,3-dione, acenaphthoquinone, arylamines, and active methylenes under solvent-free conditions at 80 degrees C. Fe3O4@SiO2@Pr-N (CH2CH2-OBuSO3H)(3) with high magnetical and nontoxic properties has a core-shell structure. The molecular docking was performed against the cancer target like the crystal structure of the motor protein kinesin spindle protein in complex with adenosine-5'-diphosphate and monastrol (pdb: 1Q0B) (2) and crystal structure of Mcl-1 in complex with compound 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid (pdb: 3WIX) (3).