Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of EVD increases and with the development and approval of medical countermeasures (MCMs) against the acute disease, late phases of EVD, including sequelae, recrudescence, and viral persistence, are occuring more frequently and are now a focus of ongoing research. Existing animal disease models recapitulate acute EVD but are not suitable to investigate the mechanisms of these late disease phenomena. Although there are challenges in establishing such a late disease model, the filovirus research community has begun to call for the development of an EBOV persistence model to address late disease concerns. Ultimately, this will aid the development of MCMs against late disease and benefit survivors of future EVD and filovirus outbreaks.
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Hosp Trop Dis, 2B Maple House,149 Tottenham Court Rd, London W1T 7DN, EnglandHosp Trop Dis, 2B Maple House,149 Tottenham Court Rd, London W1T 7DN, England
Lever, Robert A.
Whitty, Christopher J. M.
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Hosp Trop Dis, 2B Maple House,149 Tottenham Court Rd, London W1T 7DN, EnglandHosp Trop Dis, 2B Maple House,149 Tottenham Court Rd, London W1T 7DN, England
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Univ Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USAUniv Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA
Kaul, D. R.
Mehta, A. K.
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Emory Univ, Sch Med, Div Infect Dis, Dept Internal Med, Atlanta, GA USAUniv Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA
Mehta, A. K.
Wolfe, C. R.
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Duke Univ, Sch Med, Div Infect Dis, Dept Internal Med, Durham, NC USAUniv Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA
Wolfe, C. R.
Blumberg, E.
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Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15261 USA
Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USAUniv Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA
Blumberg, E.
Green, M.
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Univ Penn, Sch Med, Div Infect Dis, Dept Internal Med, Philadelphia, PA 19104 USAUniv Michigan, Div Infect Dis, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA