Ebola virus disease sequelae and viral persistence in animal models: Implications for the future

被引:1
|
作者
Durant, Olivia [1 ]
Marzi, Andrea [1 ]
机构
[1] NIAID, Div Intramural Res, Lab Virol, NIH, Hamilton, MT 20852 USA
关键词
MARBURG VIRUS; TRANSMISSION;
D O I
10.1371/journal.ppat.1012065
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of EVD increases and with the development and approval of medical countermeasures (MCMs) against the acute disease, late phases of EVD, including sequelae, recrudescence, and viral persistence, are occuring more frequently and are now a focus of ongoing research. Existing animal disease models recapitulate acute EVD but are not suitable to investigate the mechanisms of these late disease phenomena. Although there are challenges in establishing such a late disease model, the filovirus research community has begun to call for the development of an EBOV persistence model to address late disease concerns. Ultimately, this will aid the development of MCMs against late disease and benefit survivors of future EVD and filovirus outbreaks.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] Ebola virus disease: emergence, outbreak and future directions
    Lever, Robert A.
    Whitty, Christopher J. M.
    BRITISH MEDICAL BULLETIN, 2016, 117 (01) : 95 - 106
  • [22] Sequelae and Other Conditions in Ebola Virus Disease Survivors, Sierra Leone, 2015
    Mohammed, Hamish
    Vandy, Alren O.
    Stretch, Rebecca
    Otieno, David
    Prajapati, Mukesh
    Calderon, Mauricio
    Vandi, Mohamed
    EMERGING INFECTIOUS DISEASES, 2017, 23 (01) : 66 - 73
  • [23] Diagnosis of Ebola Virus Disease: Past, Present, and Future
    Broadhurst, M. Jana
    Brooks, Tim J. G.
    Pollock, Nira R.
    CLINICAL MICROBIOLOGY REVIEWS, 2016, 29 (04) : 773 - 793
  • [24] Implications of Ebola virus disease on wildlife conservation in Nigeria
    Egbetade, Adeniyi Olugbenga
    Sonibare, Adekayode Olanrewaju
    Meseko, Clement Adebajo
    Jayeola, Omotola Abiola
    Otesile, Ebenezer Babatunde
    PAN AFRICAN MEDICAL JOURNAL, 2015, 22 : 16
  • [25] Ebola Virus Disease: Implications for Solid Organ Transplantation
    Kaul, D. R.
    Mehta, A. K.
    Wolfe, C. R.
    Blumberg, E.
    Green, M.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15 (01) : 5 - 6
  • [26] Ebola virus persistence in aqueous humor and 12-month outcomes of cataract surgery in survivors of Ebola virus disease
    Bishop, Rachel
    Ross, Robin Demi
    Shantha, Jessica
    Hayek, Brent
    Gradin, Daniel
    Roberts, Benjamin
    Crozier, Ian
    Higgs, Elizabeth
    Dolo, Robert
    Amegashie, Fred
    Singh, Gurcharan
    Nishant, Kumar
    Van Ryn, Collin
    Reilly, Cavan
    Yeh, Steven
    Eghrari, Allen O.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [27] Virus persistence and recrudescence after Ebola virus disease: what are the risks to healthcare workers?
    MacDermott, N. E.
    Bausch, D. G.
    JOURNAL OF HOSPITAL INFECTION, 2016, 94 (02) : 113 - 115
  • [28] Improved uniform persistence for partially diffusive models of infectious diseases: cases of avian influenza and Ebola virus disease
    Covington, Ryan
    Patton, Samuel
    Walker, Elliott
    Yamazaki, Kazuo
    MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2023, 20 (11) : 19686 - 19709
  • [29] An analysis of features of pathogenesis in two animal models of Ebola virus infection
    Ryabchikova, EI
    Kolesnikova, LV
    Luchko, SV
    JOURNAL OF INFECTIOUS DISEASES, 1999, 179 : S199 - S202
  • [30] Mucosal Challenge Ferret Models of Ebola Virus Disease
    Brasel, Trevor
    Comer, Jason E.
    Massey, Shane
    Smith, Jeanon
    Smith, Jennifer
    Hyde, Matthew
    Kocsis, Andrew
    Gainey, Melicia
    Niemuth, Nancy
    Triplett, Cheryl
    Rudge, Thomas, Jr.
    PATHOGENS, 2021, 10 (03): : 1 - 17