Histone modification: Biomarkers and potential therapies in colorectal cancer

被引：9
|
作者：
An, Xin [1 ]
Lan, Xiaohua [2 ]
Feng, Zizhen [2 ]
Li, Xiaohong [3 ,4 ]
Su, Qisheng [3 ,4 ]
机构：
[1] Guangxi Med Univ, Clin Med Coll 1, Nanning, Guangxi, Peoples R China
[2] Guangxi Med Univ, Sch Basic Med, Nanning, Guangxi, Peoples R China
[3] Guangxi Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Med Guangxi, Dept Clin Lab,Dept Educ, Nanning, Guangxi, Peoples R China
[4] Guangxi Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Med Guangxi, Dept Clin Lab,Dept Educ, 6 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China
来源：
ANNALS OF HUMAN GENETICS | 2023年 / 87卷 / 06期
关键词：
biomarkers; colorectal cancer; drug targets; epigenetics; histone modifications; DNA METHYLATION; ACETYLATION; EXPRESSION; PHOSPHORYLATION; CONTRIBUTES; EPIGENETICS; CELLS;
D O I：
10.1111/ahg.12528
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The complex mechanism of colorectal cancer development is closely associated with epigenetic modifications and is caused by overexpression and/or inactivation of oncogenes. Histone modifying enzymes catalyze histone modifications to alter gene expression, which plays a crucial role in the development and progression of colorectal cancer. Currently, there is more frequent study on histone acetylation, methylation, and phosphorylation, and their mechanisms in colorectal cancer development are clearer. This article elaborates on the role of histone modification in epigenetics in colorectal cancer development and discusses recent advances in using it as biomarkers and therapeutic targets for the treatment of colorectal cancer. The review aims to demonstrate the significant role of histone modification as a new therapeutic target in colorectal cancer and provides insights into the novel diagnostic and therapeutic options it offers.
引用
收藏
页码：274 / 284
页数：11
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