Objective: To investigate the risk factors of postpartum hemorrhage in single primiparas. Methods: The clinical data of 532 cases of single primiparas who delivered in the First Affiliated Hospital of Jinan University from August 2020 to December 2020 were retrospectively analyzed, and the primiparas were divided into the bleeding group (32 cases) and the non-bleeding group (500 cases) according to postpartum hemorrhaging or not. The gen-eral conditions, medical history, psychological status and the pregnancy process of the two groups were compared, and logistic regression was used to analyze the high-risk factors of postpartum hemorrhage in singleton primiparas. Results: The comparison of uterine fatigue, hemoglobin content, and prenatal GAD-7 score between the two groups was statistically significant (P < 0.05), which were the high-risk factors for postpartum hemorrhage in single pri-mipara women. Conclusions: The incidence of postpartum hemorrhage in primiparas was 6.02%, and uterine weak-ness, antenatal anxiety, and moderate to severe anemia were the influencing factors of postpartum hemorrhage in primiparas. Timely correction of anemia before childbirth, psychological guidance for primiparas' anxiety, prenatal education, and early prevention of postpartum hemorrhage caused by uterine weakness are very important for reducing the incidence of postpartum hemorrhage.