Platelet-Rich Fibrin in Oral Surgery and Endodontic Procedures as a Regenerative Biomaterial: A Review Article

Background: One of the major challenges in clinical research is to incorporate materials and procedures into dentistry that can improve clinical outcomes, increasing percentages of success. Platelet-rich fibrin (PRF) is a surgical, biological additive prepared by manipulation of autologous blood, which stimulates and regulates inflammation during and after oral surgery. This study aims to assess the potential benefits of using PRF in modern oral and endodontic surgery to accelerate radiographic healing and reduce postoperative discomfort. Methods and Results: Electronic literature research was conducted using the biomedical search engine "National Library of Medicine," PubMed/MEDLINE database from March 2000 to June 2023. To obtain results that involved the whole scope of dentistry and PRF, the keywords used for the search were "PRF," "PRF in dentistry," and "PRF on apical surgery." The articles were selected by reviewing the titles and abstracts of the articles with the word "platelet-rich fibrin (PRF)." Articles related only to clinical applications in general dentistry and its different application fields were hand-searched in applicable, significant journals, and reference lists of included studies were broadcast with no language limitation. The inclusion criteria set for this review were as follows: all case reports, case series, original research papers, review papers, in vitro/in vivo studies, animal studies, and controlled clinical trials on PRF used in dentistry-related studies. Current studies, in vitro and in vivo, have confirmed safe and encouraging results, without opposing outcomes, related to the use of PRF alone or in a mixture with other biomaterials. The use of PRF treatment has been shown to enhance and promote natural tissue healing support.