NEUTROPHIL HETEROGENEITY IN SEPSIS: THE ROLE OF DAMAGE-ASSOCIATED MOLECULAR PATTERNS

被引:12
|
作者
Murao, Atsushi [1 ,5 ]
Aziz, Monowar [1 ,2 ,3 ]
Wang, Ping [1 ,2 ,3 ,4 ]
机构
[1] Feinstein Inst Med Res, Ctr Immunol & Inflammat, Manhasset, NY USA
[2] Zucker Sch Med Hofstra Northwell, Dept Mol Med, Manhasset, NY USA
[3] Zucker Sch Med Hofstra Northwell, Dept Surg, Manhasset, NY USA
[4] Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA
[5] Feinstein Inst Med Res, Ctr Immunol & Inflammat, 350 Community Dr, Manhasset, NY 11030 USA
来源
SHOCK | 2023年 / 59卷 / 02期
基金
美国国家卫生研究院;
关键词
DAMPs; eCIRP; HMGB1; inflammation; NETs; neutrophil; sepsis; APN-antigen-presenting neutrophils; DAMPs-damage-associated molecular patterns; eCIRP-extracellular cold-inducible RNA-binding protein; HMGB1-high-mobility group box 1; HSP-heat shock protein; ICAM-1-intercellular adhesion molecule-1; LDN-low-density neutrophils; MPO-myeloperoxidase; NE-neutrophil elastase; NETs-neutrophil extracellular traps; OLFM4-olfactomedin; 4; PRRs-pattern recognition receptors; RMN-reverse-migrated neutrophils; Siglec-F-sialic-acid-binding immunoglobulin-like lectin-F; TLRs-toll-like receptors; TREM-1-triggering receptor expressed on myeloid cells-1; LOW-DENSITY NEUTROPHILS; INFLAMMATION; EXPRESSION; CELLS; DIFFERENTIATION; IDENTIFICATION; LETHALITY; MEDIATORS; HISTONES; DEATH;
D O I
10.1097/SHK.0000000000002019
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host response to infection. Neutrophils act as the first line of defense against pathogens by releasing effector molecules such as reactive oxygen species, myeloperoxidase, and neutrophil extracellular traps. However, uncontrolled activation of neutrophils and extensive release of effector molecules often cause a "friendly fire" to damage organ systems. Although neutrophils are considered a short-lived, terminally differentiated homogeneous population, recent studies have revealed its heterogeneity comprising different subsets or states implicated in sepsis pathophysiology. Besides the well-known N1 and N2 subsets of neutrophils, several new subsets including aged, antigen-presenting, reverse-migrated, intercellular adhesion molecule-1(+), low-density, olfactomedin 4(+), and Siglec-F+ neutrophils have been reported. These neutrophils potentially contribute to the pathogenesis of sepsis based on their proinflammatory and immunosuppressive functions. Damage-associated molecular patterns (DAMPs) are endogenous molecules to induce inflammation by stimulating pattern recognition receptors on immune cells. Different kinds of DAMPs have been shown to contribute to sepsis pathophysiology, including extracellular cold-inducible RNA-binding protein, high-mobility group box 1, extracellular histones, and heat shock proteins. In this review, we summarize the different subsets of neutrophils and their association with sepsis and discuss the novel roles of DAMPs on neutrophil heterogeneity.
引用
收藏
页码:239 / 246
页数:8
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