The Research Progress in Transforming Growth Factor-β2

被引：3

作者：

Wang, Meng-Yan ^{[1
]}

Liu, Wen-Juan ^{[1
]}

Wu, Le-Yi ^{[1
]}

Wang, Gang ^{[1
]}

Zhang, Cheng-Lin ^{[1
,2
]}

Liu, Jie ^{[1
]}

机构：

[1] Shenzhen Univ, Dept Pathophysiol, Med Sch, Shenzhen 518060, Peoples R China

[2] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518000, Peoples R China

来源：

CELLS | 2023年 / 12卷 / 23期

关键词：

transforming growth factor-beta 2; regulation; signalling pathway; biological function; GROWTH-FACTOR-BETA; LATENT TGF-BETA; EPITHELIAL-CELLS; ENDOTHELIAL-CELLS; BINDING-PROTEINS; DOWN-REGULATION; III RECEPTOR; EXPRESSION; TGF-BETA-2; ACTIVATION;

D O I：

10.3390/cells12232739

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor-beta 2 (TGF-beta 2), an important member of the TGF-beta family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-beta 2 had been thought to be functionally identical to TGF-beta 1; however, an increasing number of recent studies uncovered the distinctive features of TGF-beta 2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-beta 2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-beta 2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-beta 2 to support further research on TGF-beta 2.

引用

页数：21

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