Chemical composition of the White Sea sponge Halichondriа panicea

被引:0
|
作者
Krasnov, Konstantin A. [1 ]
Gorbunov, Alexander Yu [2 ]
Rogovskaja, Nadezhda Yu [2 ]
Utsal, Viktor A. [1 ]
Papp, Vladimir T. [1 ]
Krasnova, Alexandra A. [1 ]
Gaft, Semen S. [1 ]
Khalaman, Vyacheslav V. [3 ]
机构
[1] Fed Med Biol Agcy, Golikov Res Clin Ctr Toxicol, St Petersburg, Russia
[2] Res Inst Hyg Occupat Pathol & Human Ecol, St Petersburg, Russia
[3] Russian Acad Sci, Zool Inst, White Sea Biol Stn, St Petersburg 199034, Russia
关键词
Sponge; Halichondria panicea; White Sea; chemical composition; profiling; metabolome; HALICHONDRIA-PANICEA; MARINE SPONGES; DIKETOPIPERAZINES; METABOLITES; POLYETHER; PRODUCTS;
D O I
10.1080/14786419.2024.2333049
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The extract of the White Sea sponge Halichondria panicea (Pallas, 1766) exhibits cytotoxic and cytostatic effects. The main part of the extract consists of hydrophilic low molecular weight compounds: free amino acids (13.9%), glucose (19.9%), polyatomic alcohols (glycerin and others) (6.1%), carboxylic acids (0.7%) and nitrogenous heterocycles (1.2%). Of the substances specific to the metabolome, bicyclic diketopiperazines (four derivatives), pyroglutamic acid, phenylacetic acid, and two steroids (3 beta,5 alpha)cholest-7-en-3-ol and dihydrocholesterol were identified. Toxicants characteristic of the genus Halichondria were not found in the White Sea sponge.
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页数:8
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