Cross-Talk Between Thyroid Disorders and Nonalcoholic Fatty Liver Disease: From Pathophysiology to Therapeutics

被引：0

作者：

Yang, Yan ^{[1
]}

Xiao, Jiyuan ^{[2
]}

Qiu, Wen ^{[2
]}

Jiang, Luxia ^{[3
]}

机构：

[1] Lanzhou Univ Second Hosp, Dept Endocrinol & Metab, Lanzhou, Peoples R China

[2] Lanzhou Univ Second Hosp, Dept Pharmacol, Lanzhou, Peoples R China

[3] Lanzhou Univ Second Hosp, Dept Cardiac Surg ICU, Cuiyingmen 82, Lanzhou 730030, Peoples R China

来源：

HORMONE AND METABOLIC RESEARCH | 2024年 / 56卷 / 10期

基金：

中国国家自然科学基金;

关键词：

thyroid disorders; NAFLD; pathophysiology; therapeutics; RECEPTOR-BETA AGONISTS; HORMONE RECEPTOR; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; HEPATIC STEATOSIS; EXPRESSION; 3,5-DIIODO-L-THYRONINE; CHOLESTEROL; METABOLISM; ACTIVATION;

D O I：

10.1055/a-2276-7973

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The medical community acknowledges the presence of thyroid disorders and nonalcoholic fatty liver disease (NAFLD). Nevertheless, the interconnection between these two circumstances is complex. Thyroid hormones (THs), including triiodothyronine (T3) and thyroxine (T4), and thyroid-stimulating hormone (TSH), are essential for maintaining metabolic balance and controlling the metabolism of lipids and carbohydrates. The therapeutic potential of THs, especially those that target the TR beta receptor isoform, is generating increasing interest. The review explores the pathophysiology of these disorders, specifically examining the impact of THs on the metabolism of lipids in the liver. The purpose of this review is to offer a thorough analysis of the correlation between thyroid disorders and NAFLD, as well as suggest potential therapeutic approaches for the future.

引用

页码：697 / 705

页数：9

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