Prediction of initial objective response to drug-eluting beads transcatheter arterial chemoembolization for hepatocellular carcinoma using CT radiomics-based machine learning model

被引:4
|
作者
Zhang, Xueying [1 ]
He, Zijun [1 ]
Zhang, Yucong [2 ]
Kong, Jian [3 ]
机构
[1] Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
[2] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Clin Med Coll 2, Dept Radiat Oncol,Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
[3] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1, Dept Intervent Radiol,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
关键词
hepatocellular carcinoma; drug-eluting beads transcatheter arterial chemoembolization; initial response; objective response; computed tomography; radiomics; nomogram; prediction; TRANSARTERIAL CHEMOEMBOLIZATION; LIVER-CANCER; TIME-POINT; DC BEAD; MRECIST; CLASSIFICATION; SURVIVAL; HETEROGENEITY; SYSTEM; EASL;
D O I
10.3389/fphar.2024.1315732
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: A prognostic model utilizing CT radiomics, radiological, and clinical features was developed and validated in this study to predict an objective response to initial transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC).Methods: Between January 2017 and December 2022, the baseline clinical characteristics and preoperative and postoperative follow-up imaging data of 108 HCC patients who underwent the first time treatment of DEB-TACE were analyzed retrospectively. The training group (n = 86) and the validation group (n = 22) were randomly assigned in an 8:2 ratio. By logistic regression in machine learning, radiomics, and clinical-radiological models were constructed separately. Finally, the integrated model construction involved the integration of both radiomics and clinical-radiological signatures. The study compared the integrated model with radiomics and clinical-radiological models using calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA).Results: The objective response rate observed in a group of 108 HCC patients who received initial DEB-TACE treatment was found to be 51.9%. Among the three models, the integrated model exhibited superior predictive accuracy in both the training and validation groups. The training group resulted in an area under the curve (AUC) of 0.860, along with sensitivity and specificity values of 0.650 and 0.913, respectively. Based on the findings from the validation group, the AUC was estimated to be 0.927. Additionally, it was found that values of sensitivity and specificity were 0.875 and 0.833, respectively. In the validation group, the AUC of the integrated model showed a significant improvement when contrasted to the clinical-radiological model (p = 0.042). Nevertheless, no significant distinction was observed in the AUC when comparing the integrated model with the radiomics model (p = 0.734). The DCA suggested that the integrated model demonstrates advantageous clinical utility.Conclusion: The integrated model, which combines the CT radiomics signature and the clinical-radiological signature, exhibited higher predictive efficacy than either the radiomics or clinical-radiological models alone. This suggests that during the prediction of the objective responsiveness of HCC patients to the first DEB-TACE treatment, the integrated model yields superior outcomes.
引用
收藏
页数:17
相关论文
共 50 条
  • [41] Quantification of Functional MR Predicts Early Response in Post-doxorubicin Drug-Eluting Beads Chemoembolization for Hepatocellular Carcinoma
    Hsin-You Ou
    Yu-Fan Cheng
    Yi-Hsuan Chuang
    Hsien-Wen Hsu
    Chao-Long Chen
    Marirose Zingapan Lazo
    Ching-Chun Weng
    Chun-Yen Yu
    Leo Leung-Chit Tsang
    Tung-Liang Huang
    Yu-Shun Tong
    Digestive Diseases and Sciences, 2020, 65 : 2433 - 2441
  • [42] Efficacy of intra-arterial contrast-enhanced ultrasonography during transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma
    Shiozawa, Kazue
    Watanabe, Manabu
    Ikehara, Takashi
    Yamamoto, Shuhei
    Matsui, Takashi
    Saigusa, Yoshinori
    Igarashi, Yoshinori
    Maetani, Iruru
    WORLD JOURNAL OF HEPATOLOGY, 2018, 10 (01) : 95 - 104
  • [43] Radiological characteristics of hepatocellular carcinoma that achieved complete response after chemoembolization with drug-eluting beads for liver transplantation planning
    Valle, Leonardo Guedes Moreira
    Cunha, Marcela Juliano Silva
    Schmid, Bruno Pagnin
    Falsarella, Priscila Mina
    de Rezende, Marcelo Bruno
    Felga, Guilherme Eduardo Goncalves
    Ogawa, Renata Emy
    Garcia, Rodrigo Gobbo
    Affonso, Breno Boueri
    Nasser, Felipe
    Galastri, Francisco Leonardo
    EINSTEIN-SAO PAULO, 2023, 21 : eAO0307
  • [44] Comparison of RECIST, mRECIST, and Choi Criteria for Early Response Evaluation of Hepatocellular Carcinoma After Transarterial Chemoembolization Using Drug-Eluting Beads
    Yeo, Dong Myung
    Choi, Joon-Il
    Lee, Young Joon
    Park, Michael Y.
    Chun, Ho Jong
    Lee, Hae Giu
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2014, 38 (03) : 391 - 397
  • [45] Quantification of Functional MR Predicts Early Response in Post-doxorubicin Drug-Eluting Beads Chemoembolization for Hepatocellular Carcinoma
    Ou, Hsin-You
    Cheng, Yu-Fan
    Chuang, Yi-Hsuan
    Hsu, Hsien-Wen
    Chen, Chao-Long
    Lazo, Marirose Zingapan
    Weng, Ching-Chun
    Yu, Chun-Yen
    Tsang, Leo Leung-Chit
    Huang, Tung-Liang
    Tong, Yu-Shun
    DIGESTIVE DISEASES AND SCIENCES, 2020, 65 (08) : 2433 - 2441
  • [46] Switching the Loaded Agent from Epirubicin to Cisplatin: Salvage Transcatheter Arterial Chemoembolization with Drug-eluting Microspheres for Unresectable Hepatocellular Carcinoma
    Seki, Akihiko
    Hori, Shinich
    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 35 (03) : 555 - 562
  • [47] Switching the Loaded Agent from Epirubicin to Cisplatin: Salvage Transcatheter Arterial Chemoembolization with Drug-eluting Microspheres for Unresectable Hepatocellular Carcinoma
    Akihiko Seki
    Shinich Hori
    CardioVascular and Interventional Radiology, 2012, 35 : 555 - 562
  • [48] Surgical resection versus radiofrequency ablation plus drug-eluting beads transcatheter arterial chemoembolization for the treatment of solitary large hepatocellular carcinoma. A single center experience
    Saviano, Antonio
    Iezzi, Roberto
    Giuliante, Felice
    Salvatore, Lucia
    Mele, Caterina
    Posa, Alessandro
    Campanale, Mariachiara
    Rinninella, Emanuele
    Cesario, Valentina
    Barbaro, Federico
    Biolato, Marco
    Zocco, Maria Assunta
    Riccardi, Laura
    Annicchiarico, Brigida E.
    Siciliano, Massimo
    De Gaetano, Anna Maria
    Grieco, Antonio
    Rapaccini, Gian Ludovico
    Gasbarrini, Antonio
    Bonomo, Lorenzo
    Pompili, Maurizio
    HEPATOLOGY, 2015, 62 : 427A - 427A
  • [49] Prognostic significance of arterial phase CT for prediction of response to transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma: A retrospective analysis
    Katyal, S
    Oliver, JH
    Peterson, MS
    Chang, PJ
    Baron, RL
    Carr, BI
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 175 (06) : 1665 - 1672
  • [50] Transarterial chemoembolization using drug-eluting beads versus lipiodol in the treatment of unresectable hepatocellular carcinoma: propensity score matching
    Cao, Gengfei
    Gu, Junpeng
    Zhang, Haixiao
    Ji, Weizheng
    Zhu, Diwen
    Bao, Yingjun
    Asi, Haer
    Ren, Weixin
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2024, 15 (03) : 1101 - 1111