Objective: To analyse the factors associated with preventable of infant mortality, in Espirito Santo, Brazil.Methods: Data were collected from records of notifiable of infant death of the Mortality Infor-mation System. A total of 5,089 infant deaths were classified as preventable and non-preventable according to the International Collaborative Effort on Infant Mortality (ICE) and the State System of Data Analysis Foundation (SEADE) methods. To investigate the factors associated with pre-ventable of deaths, it was applied the logistic regression.Results: Approximately, 73% of the deaths were preventable according to the ICE, while 76% were preventable according to the SEADE method. Using to both methods, it was observed that preterm birth, postneonatal death and birth weight between 3000 and above 4,000 g represented higher chances for preventable infant deaths. Furthermore, the medical care was more likely to pre-ventable infant death only for ICE method.Conclusions: The factors related to the quality of care offered in the prenatal, prepartum and childbirth periods were more relevant for the occurrence of preventable infant death. Accord-ingly, it is recommended to strengthen mother-child care to detect risk pregnancies during pre-natal care, as well as a hierarchical, regionalized and integrated perinatal network.